Inhibition of Na+,K+ -ATPase enzyme by tetrodotoxin extract in the breast tumor xenograft Balb/c nu mouse model
Our results indicate that TTX extract may have anti-tumor effects by inhibiting NKA activity. Therefore, considering the presence of TTX in the pufferfish extract, TTX could be a promising therapeutic candidate for controlling metastatic breast tumor growth and metastasis through NKA inhibition.
Authors
- Ameneh Ahrari
- Haleh Akhavan‐Niaki (ORCID: https://orcid.org/0000-0003-3681-0227)
- Hadi Zare‐Zardini (ORCID: https://orcid.org/0000-0002-1501-2560)
- Saber Khodabandeh (ORCID: https://orcid.org/0000-0002-6697-7215)
Institutions
- Tarbiat Modares University (IR)
- Mofid University (IR)
- Islamic Azad University Maybod (IR)
- Babol University of Medical Sciences (IR)
Publication Details
- Journal
- BioMedical Engineering OnLine
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s12938-025-01479-1
- Primary Topic
- Polyamine Metabolism and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tarbiat Modares University