Complement factor D (adipsin) mediates pressure-pain hypersensitivity post destabilization of medial meniscus injury
The absence of Cfd protects cartilage but does not prevent hyperalgesia after DMM. Changes in eicosanoid profiles suggests that loss in FD drives pain acutely and creates a hyperalgesia phenotype early in response to DMM. Eicosanoid profiling is a novel tool to mechanistically determine pain drivers in osteoarthritis.
Authors
- Hope D. Welhaven (ORCID: https://orcid.org/0000-0001-9330-6903)
- A. González Gómez
- Priscilla M. Tjandra (ORCID: https://orcid.org/0000-0001-8771-3422)
- Kelsey H. Collins (ORCID: https://orcid.org/0000-0001-7348-7348)
- Tri Nhut Pham (ORCID: https://orcid.org/0000-0002-9205-7789)
- J. Kim
- Jacob G. Brockert
- Bethany A. Andoko
- Sonya Sar
- Megha R. Aepala
- Darren Dumlao
Institutions
- University of California, San Francisco (US)
- UCSF Benioff Children's Hospital (US)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s13075-025-03678-6
- Citations
- 3
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.00
Funders
- Washington University in St. Louis
- National Research Foundation
- National Institutes of Health
- University of California, San Francisco
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Center for Research Resources