Iatrogenic cerebral amyloid angiopathy 30 years after childhood cadaveric dura mater transplantation: a case report
These findings suggest that abnormal Aβ may have gradually propagated over decades from the transplanted cadaveric dura mater, resulting in CAA. Including this case, thirteen LYODURA-associated cases have been reported, with disease onset occurring more than 30 years after head surgery and dural transplantation. Until 1997, a large volume of LYODURA was imported into Japan, raising the possibility of additional future cases of CAA. This case highlights the importance of considering iatrogenic CAA in younger patients and demonstrates the potential value of non-invasive detection through amyloid PET.
Authors
- Nobutaka Hattori (ORCID: https://orcid.org/0000-0002-2034-2556)
- R. Nakamura (ORCID: https://orcid.org/0000-0003-2975-1265)
- Takeshi Ikeuchi (ORCID: https://orcid.org/0000-0001-8828-8085)
- Go Matsuoka (ORCID: https://orcid.org/0000-0003-0417-1432)
- Takao Urabe (ORCID: https://orcid.org/0000-0002-3204-0010)
- Masataka Kato
- Ichiro Takai
- Kazuo Yamashiro (ORCID: https://orcid.org/0000-0002-0948-3657)
- Takashi Ogawa (ORCID: https://orcid.org/0000-0002-7335-0672)
- Masao Watanabe (ORCID: https://orcid.org/0009-0002-7062-6773)
- Yutaka Oji (ORCID: https://orcid.org/0000-0001-9778-0899)
- Daisuke Taniguchi (ORCID: https://orcid.org/0000-0002-8729-7016)
- Y. Imanishi
- Ai Yayama
Institutions
- Juntendo University (JP)
- Juntendo University Urayasu Hospital (JP)
- Edogawa Hospital (JP)
- Niigata University (JP)
Publication Details
- Journal
- BMC Neurology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s12883-025-04506-9
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development