Anti-CENP-A/B reactivity in samples exhibiting the centromere HEp-2 pattern is associated with a lower frequency of interstitial lung disease in limited cutaneous systemic sclerosis patients
ILD was less frequent in lcSSc patients with a positive AC-3 pattern as compared to those with a non-AC-3 pattern, which could suggest a less severe prognosis. In addition, anti-CENP-B was the predominant autoantibody in samples yielding the AC-3 pattern, but anti-CENP-A reactivity was also prevalent, and exclusive anti-CENP-A reactivity was also observed.
Authors
- Luís Eduardo Coelho Andrade (ORCID: https://orcid.org/0000-0001-8742-9931)
- Sílvia Helena Rodrigues (ORCID: https://orcid.org/0000-0001-5005-2771)
- Larissa Diogenes (ORCID: https://orcid.org/0000-0001-8015-1383)
- Cristiane Kayser (ORCID: https://orcid.org/0000-0003-0543-5305)
- Gerson Dierley Keppeke (ORCID: https://orcid.org/0000-0003-0660-2857)
- Diana Landoni (ORCID: https://orcid.org/0000-0001-7906-4063)
- Jessica Keppeke
- Pedro Matos (ORCID: https://orcid.org/0000-0002-3734-1103)
Institutions
- Universidad de la República de Uruguay (UY)
- Universidad Católica del Norte (CL)
- Observatorio Astronómico Los Molinos (UY)
- Fleury S.A. (Brazil) (BR)
- Hospital de Clínicas (UY)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Journal of Circulating Biomarkers
- Published
- 2025-11-26
- DOI
- https://doi.org/10.33393/jcb.2025.3608
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00