CAFs-derived SPI1 in tumor fibroblasts promotes malignant behaviors of liver cancer cells and immune escape by regulating HRAS and PD-L1 transcription
SPI1 derived from CAFs facilitates the malignant behaviors of HCC cells by up-regulating v-Ha-ras Harvey rat sarcoma viral oncogene homolog (HRAS) expression. This study enriches our understanding of HCC at the molecular level and may pave the way for the development of a novel strategy for the treatment of HCC.
Authors
- Ke Miao (ORCID: https://orcid.org/0000-0003-4018-2446)
- Jingjing Zhou (ORCID: https://orcid.org/0000-0001-7855-3615)
- Jieyun Chen (ORCID: https://orcid.org/0000-0002-4129-1348)
Institutions
- Hebei Medical University (CN)
- Xingtai People's Hospital (CN)
- Yiwu Science and Technology Research Institute (CN)
Publication Details
- Journal
- Hereditas
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s41065-025-00605-2
- Citations
- 1
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.05