Evaluation of the relative benefits of FFR-guided, angiography-guided CR or culprit-only revascularization in patients with multivessel coronary disease: a systematic review and meta-analysis

FFR-guided CR was found to linked with reduced repeat revascularization and TLR in individuals with CAD and MVD in comparison with culprit-only PCI. While no significant difference was detected between FFR-guided and angiography-guided CR procedures for the analyzed cardiovascular outcomes, a lower absolute number of adverse events was noted with FFR-guided CR. These findings indicate that the FFR-guided CR of non-culprit vessels may help reduce the need for the implantation of stents in patients with CAD and MVD without any adverse impact on their prognostic outcomes.