Protective effects of mouse bone marrow mesenchymal stem cell-derived extracellular vesicles on radiation-induced epididymal cells damage via USP44/RBM14 axis
Our findings reveal a novel USP44/RBM14 axis mediated by mBMSC-EVs that counteracts radiation injury, and suggest this mechanism as a promising therapeutic approach for protecting reproductive tissues from radiation-induced damage. Notably, these findings are primarily grounded in in vitro experiments utilizing an immortalized epididymal cell line; further in vivo validation and evaluation of clinical translatability are required prior to therapeutic application.
Authors
- Yuanhang Cheng (ORCID: https://orcid.org/0000-0002-3062-9593)
- Wenyi Deng (ORCID: https://orcid.org/0000-0003-0616-9993)
- Jianping Zhang (ORCID: https://orcid.org/0000-0002-1929-792X)
- Jin Chen (ORCID: https://orcid.org/0000-0003-0794-3995)
- Lingfeng Zhu
- Lingling Lin (ORCID: https://orcid.org/0000-0003-4598-5280)
- Na Lin
- Yaoyao Liang
Institutions
- Huaqiao University (CN)
- Fujian Medical University (CN)
- The 180th Hospital of PLA (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- The First People's Hospital of Tianmen (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s13287-025-04782-9
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hainan Medical University
- Fujian Medical University