Crosstalk of NPY and TGFβ orchestrates the signaling to facilitate perineural invasion of oral squamous cell carcinoma
We identify NPY-NPY1R-TGFβ crosstalk as a novel mechanism enabling OSCC to exploit neural signals for PNI, highlighting a promising therapeutic target to block neural invasion and improve patient outcomes.
Authors
- Guangxiang Zang (ORCID: https://orcid.org/0000-0002-3081-4780)
- Yabing Mu (ORCID: https://orcid.org/0000-0003-3193-1425)
- Jinhui Wei
- Ketong Liu (ORCID: https://orcid.org/0000-0003-3020-7275)
- Y.-H. Luo (ORCID: https://orcid.org/0009-0007-9999-1826)
- Maréne Landström (ORCID: https://orcid.org/0000-0001-6737-7230)
- Zhengyan Liu
- Jiahao Tao (ORCID: https://orcid.org/0000-0001-8950-3613)
- Jing Bi (ORCID: https://orcid.org/0000-0001-9921-9990)
Institutions
- Umeå University (SE)
- China Medical University (CN)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1038/s41416-025-03261-5
- Citations
- 1
- Primary Topic
- TGF-β signaling in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- China Medical University
- Cancerforskningsfonden i Norrland