Immunosuppressants rewire the gut microbiome-alloimmune axis through time-dependent and tissue-specific mechanisms
Together, our findings show that immunosuppressants elicit complex, time-dependent effects that remodel the gut and exert compartment-specific impacts on lymphoid tissues, differentially affecting gut-draining mesenteric versus peripheral LN. Understanding these relationships offers new opportunities for refining immunosuppressive strategies to reduce treatment-related off-target complications and improve long-term organ transplant outcomes.
Authors
- Ram Lakhan (ORCID: https://orcid.org/0000-0002-5267-5195)
- Vikas Saxena (ORCID: https://orcid.org/0000-0003-4816-4875)
- Allison Kensiski (ORCID: https://orcid.org/0000-0003-4813-8917)
- Lushen Li (ORCID: https://orcid.org/0000-0002-6701-7937)
- Bing Ma (ORCID: https://orcid.org/0000-0002-3488-2393)
- Brendan Lohmar
- Marina W. Shirkey
- Hnin Wai Lwin
- Yan Shu (ORCID: https://orcid.org/0000-0001-8492-1437)
- Wenji Piao (ORCID: https://orcid.org/0000-0003-0005-3930)
- Yang Song (ORCID: https://orcid.org/0000-0003-1728-687X)
- Valeria R. Mas (ORCID: https://orcid.org/0000-0001-9297-9751)
- Samuel J. Gavzy (ORCID: https://orcid.org/0000-0002-4880-0301)
- Michael France (ORCID: https://orcid.org/0000-0002-6029-0201)
- Long Wu (ORCID: https://orcid.org/0009-0007-5977-4747)
- Jonathan S. Bromberg
- Dejun Kong
Institutions
- University of Maryland, Baltimore (US)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s12964-025-02517-0
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases