Edaravone attenuates doxorubicin-induced oral mucosal injury via modulation of oxidative stress, inflammatory signaling, and the SIRT1/TLR4/NF-kB/ACE2 axis in rats
Edaravone effectively attenuates DOX-induced mucosal injury by modulating oxidative stress, inflammatory signaling, and TLR4/ACE2 pathways, suggesting therapeutic potential in mucosal protection.
Authors
- Mert Zeytinoğlu (ORCID: https://orcid.org/0000-0002-1178-9743)
- Necla Değer (ORCID: https://orcid.org/0000-0001-7239-3331)
- Derya Karabulut (ORCID: https://orcid.org/0000-0003-2067-6174)
- Oytun Erbaş (ORCID: https://orcid.org/0000-0001-5427-8428)
- Ali Tuğrul Akın (ORCID: https://orcid.org/0000-0002-1408-8571)
- Aras Erdil (ORCID: https://orcid.org/0000-0002-9582-5114)
- Hatice Aygün (ORCID: https://orcid.org/0000-0002-4272-0562)
- Mustafa Sami Demïrsoy (ORCID: https://orcid.org/0000-0001-8654-2799)
- Sefa Çolak (ORCID: https://orcid.org/0000-0002-0807-9089)
- Serdar Şavaş Gül (ORCID: https://orcid.org/0000-0003-4822-2588)
Institutions
- Sakarya University (TR)
- Usak University (TR)
- Tokat Gaziosmanpaşa Üniversitesi (TR)
- Ege University (TR)
- Biruni University (TR)
- Istinye University (TR)
- Lokman Hekim Üniversitesi (TR)
- Erciyes University (TR)
Publication Details
- Journal
- BMC Oral Health
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s12903-025-07148-y
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00