Polyethylene glycol loxenatide reduces NETosis and immunofluorescence hyperactivation in Behçet’s disease
PEX168 attenuates neutrophil hyperactivation and NETosis in Behçet's disease via ROS suppression and upstream inflammasome regulation, disrupting inflammatory signaling without provoking pyroptosis. These findings support GLP-1 RAs as a targeted treatment for neutrophil-driven autoimmune disorders.
Authors
- Fang Jia (ORCID: https://orcid.org/0000-0002-7738-8491)
- Xiaoli Wu (ORCID: https://orcid.org/0009-0008-5078-2158)
- Huiyang Sheng
Institutions
- Guangdong Province Stomatological Hospital (CN)
- Stomatology Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s40001-025-03442-1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00