PDK4 Regulates Inflammatory Injury in Acute-on-chronic Liver Failure by Phosphorylating STAT1-mediated M1 Polarization of Macrophages
PDK4 is a key pro-inflammatory regulator in ACLF by promoting M1 macrophage polarization. Targeting PDK4 may be a promising strategy to attenuate inflammation and improve clinical outcomes in ACLF.
Authors
- Sung Hwa Dong (ORCID: https://orcid.org/0000-0002-7633-8353)
- Chuan Shen (ORCID: https://orcid.org/0000-0001-9441-8093)
- Luyuan Ma (ORCID: https://orcid.org/0000-0002-1816-5175)
- Ying Xiao (ORCID: https://orcid.org/0000-0002-6855-0207)
- Xinyang Li (ORCID: https://orcid.org/0000-0002-6755-7650)
- Ruolan Gu
- Caiyan Zhao (ORCID: https://orcid.org/0000-0001-5997-4641)
Institutions
- Hebei Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
- Hebei Provincial Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Journal of Clinical and Translational Hepatology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.14218/jcth.2025.00343
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00