Vascular and Neural Transcriptomics Reveal Stage‐Dependent Pathways to Inflammation and Cognitive Dysfunction in a Rat Model of Hypertension
Our study provides new insight into mechanisms underlying hypertensive pathobiology and highlights its stage-dependent nature. This groundwork will be helpful for basic and clinical research to identify stage-dependent markers in the human disease course, investigate stage-dependent interventions besides blood pressure lowering, and better understand the relationship between poor vascular health and neurodegenerative diseases.
Authors
- Ildikò Rita Dunay (ORCID: https://orcid.org/0000-0002-9900-8605)
- Melina Westhues
- Torsten Knieß (ORCID: https://orcid.org/0000-0002-4107-3455)
- Michael Sendtner (ORCID: https://orcid.org/0000-0002-4737-2974)
- Lorena Morton (ORCID: https://orcid.org/0000-0002-3957-3848)
- Stefan Vielhaber (ORCID: https://orcid.org/0000-0002-4011-1106)
- Mahsima Khoshneviszadeh (ORCID: https://orcid.org/0000-0002-6993-4624)
- Naomi Lämmlin (ORCID: https://orcid.org/0009-0003-2096-4640)
- Sven Guenther Meuth (ORCID: https://orcid.org/0000-0003-2571-3501)
- Axel Becker (ORCID: https://orcid.org/0000-0002-3406-3558)
- Daniel Gündel (ORCID: https://orcid.org/0000-0001-9743-2325)
- Anja M. Oelschlegel (ORCID: https://orcid.org/0009-0008-0675-1469)
- Ruediger C. Braun‐Dullaeus (ORCID: https://orcid.org/0000-0003-3888-6532)
- Magali Toussaint (ORCID: https://orcid.org/0000-0002-1136-3857)
- Philipp Arndt (ORCID: https://orcid.org/0000-0002-0517-6473)
- Grażyna Dębska–Vielhaber (ORCID: https://orcid.org/0000-0002-6661-9821)
- Peter Brust (ORCID: https://orcid.org/0000-0001-5555-7058)
- Silke Appenzeller (ORCID: https://orcid.org/0000-0002-5472-8692)
- Michael Briese (ORCID: https://orcid.org/0000-0001-7137-8260)
- Hendrik Mattern (ORCID: https://orcid.org/0000-0001-5740-4522)
- Stefanie Schreiber (ORCID: https://orcid.org/0000-0003-4439-4374)
- Solveig Henneicke (ORCID: https://orcid.org/0000-0002-9103-7276)
- Jürgen Goldschmidt (ORCID: https://orcid.org/0000-0002-6986-9914)
- Alexander Dityatev (ORCID: https://orcid.org/0000-0002-0472-0553)
- Md. Hasanuzzaman (ORCID: https://orcid.org/0000-0002-8002-5747)
- Patrick Müller (ORCID: https://orcid.org/0000-0001-7458-2208)
Institutions
- German Center for Neurodegenerative Diseases (DE)
- University Hospital Leipzig (DE)
- Universitätsklinikum Würzburg (DE)
- Center for Behavioral Brain Sciences (DE)
- Heinrich Heine University Düsseldorf (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
- Leibniz Institute for Neurobiology (DE)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1161/jaha.125.040710
- Citations
- 2
- Primary Topic
- Sodium Intake and Health
- Type
- article
- Field-Weighted Citation Impact
- 2.24