Loss of Endothelial YAP/TAZ Reduces the Size of Chronic Stroke Lesions and Alters the Endothelial Environment
Our data suggest that endothelial YAP/TAZ affects the inflammatory milieu subacutely after ischemia and thereby influences the chronic course of stroke. Modulation of YAP/TAZ activity in ECs may be a promising therapeutic target to promote neuroprotection after stroke.
Authors
- Matthias Endres (ORCID: https://orcid.org/0000-0001-6520-3720)
- January Weiner (ORCID: https://orcid.org/0000-0003-1438-7819)
- Majed Kikhia (ORCID: https://orcid.org/0000-0002-7719-9455)
- Alexandra Klaus‐Bergmann (ORCID: https://orcid.org/0000-0002-1164-3322)
- Ria Göttert (ORCID: https://orcid.org/0000-0003-4756-7381)
- Michael Potente (ORCID: https://orcid.org/0000-0002-5689-0036)
- Wen Pan (ORCID: https://orcid.org/0000-0002-8866-6354)
- Dieter Beule (ORCID: https://orcid.org/0000-0002-3284-0632)
- Holger Gerhardt (ORCID: https://orcid.org/0000-0002-3030-0384)
- Samuel Knauß (ORCID: https://orcid.org/0000-0002-3046-9075)
- Karen Gertz (ORCID: https://orcid.org/0000-0002-1203-641X)
- Golo Kronenberg (ORCID: https://orcid.org/0009-0006-4254-4358)
- Marie‐Louise Herzog
Institutions
- Max Delbrück Center (DE)
- German Center for Neurodegenerative Diseases (DE)
- Humboldt-Universität zu Berlin (DE)
- German Centre for Cardiovascular Research (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Klinik und Poliklinik für Psychiatrie und Psychotherapie (DE)
- Einstein Center for Neurosciences Berlin (DE)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1161/jaha.124.040079
- Citations
- 2
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 2.30