Detrimental Effect of Plasma From Patients With Severe Aortic Stenosis on Valvular Endothelial Cells: Role of Proinflammatory Cytokines and Factor Xa
Patients with AS displayed subclinical systemic inflammation and increased FXa activity. These processes contributed to aortic VEC dysfunction, inflammation, monocytes and platelets adhesion, and thrombin generation upon exposure to AS+ plasma.
Authors
- Sandy Hmadeh
- Adrien Carmona (ORCID: https://orcid.org/0000-0002-3477-208X)
- Benjamin Marchandot (ORCID: https://orcid.org/0000-0001-7034-1466)
- Olivier Morel (ORCID: https://orcid.org/0000-0002-7295-3041)
- Patrick Ohlmann (ORCID: https://orcid.org/0000-0002-8021-2737)
- Valérie B. Schini‐Kerth (ORCID: https://orcid.org/0000-0001-9997-9287)
- Amandine Granier
- Shinnosuke Kikuchi (ORCID: https://orcid.org/0000-0003-4737-9882)
- Antonin Trimaille (ORCID: https://orcid.org/0000-0001-9279-4220)
- Laurent Sattler (ORCID: https://orcid.org/0000-0003-2702-6246)
- Dinh Phi Truong
- Manh Cuong Vu
- Laurence Jesel (ORCID: https://orcid.org/0000-0003-4742-3740)
- Ali Mroueh (ORCID: https://orcid.org/0009-0001-7760-9741)
- Francis Beras
Institutions
- Hanoi Medical University (VN)
- Hôpital Civil, Strasbourg (FR)
- Université de Strasbourg (FR)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1161/jaha.125.041701
- Citations
- 4
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.55