Exploring the role of circular RNAs in endometrial cancer progression and chemoresistance: Implications for targeted therapies

Endometrial cancer stands as a prevalent malignant tumor of the female genital tract, while showing growing incidence statistics. Circular RNAs (circRNAs) demonstrate translational value as biomarkers and therapeutic targets in endometrial cancer because they affect chemoresistance and tumor progression through miRNA interactions, which makes them attractive candidates for non-invasive diagnostic tools and targeted medical approaches. Through their miRNA sponge activity, they regulate gene expression together with their ability to modulate RNA-binding proteins, affect mRNA stability and impact the PTEN/PI3K/Akt and MAPK pathways that enable tumor growth and survival. The study demonstrates how circRNAs function through multiple mechanisms in endometrial cancer development, yet indicates their value as therapeutic targets for disease management. The paper explores how recent developments utilize circRNA strategies to combat chemoresistance alongside improving targeted therapy research. Future research must focus on optimizing detection methods while developing standardized diagnostic procedures and performing large-scale validation studies to establish clinical utility.