D-amino acid oxidase suppresses hepatocellular carcinoma via oxidizing D-amino acids
DAO appears to be a novel endogenous stemness repressor. The reduction in DAO is a critical molecular event in the evolution of HCC. Therapeutically, combined DAO and D-amino acid supplementation is a promising strategy for HCC treatment, particularly for reversing sorafenib resistance.
Authors
- Ran Meng (ORCID: https://orcid.org/0000-0001-8452-8758)
- Hongsen Chen (ORCID: https://orcid.org/0000-0002-3399-9506)
- Zishuai Li
- Yanming He
- Chao Fu (ORCID: https://orcid.org/0000-0003-3716-5725)
- Jiayi Zhao (ORCID: https://orcid.org/0000-0001-9975-9911)
- Guangwen Cao (ORCID: https://orcid.org/0000-0002-8094-1278)
- Yiwei Shi (ORCID: https://orcid.org/0000-0001-6764-1716)
- Rui Pu (ORCID: https://orcid.org/0000-0003-3366-739X)
- Wenbin Liu (ORCID: https://orcid.org/0000-0002-9080-8040)
- Yifan Chen (ORCID: https://orcid.org/0000-0002-8889-1594)
- Jun Zhao (ORCID: https://orcid.org/0000-0002-8094-9229)
- Yi Jin (ORCID: https://orcid.org/0000-0002-2696-3820)
- Yibo Ding (ORCID: https://orcid.org/0000-0002-2544-3882)
- Letian Fang
Institutions
- Second Military Medical University (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s12967-025-07399-x
- Primary Topic
- Amino Acid Enzymes and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00