Gut microbial tyramine facilitates intestinal damage and metabolic dysfunction-associated steatotic liver disease development
These results demonstrated that gut microbial tyramine effectively induced intestinal damage and facilitated MASLD development in mice. Tyramine was positively associated with the risk of MASLD in children. This study offered mechanistic insights into the pathogenesis of MASLD and opened therapeutic opportunities for such metabolic diseases.
Authors
- Xiongfeng Pan (ORCID: https://orcid.org/0000-0002-3443-6465)
- Miyang Luo (ORCID: https://orcid.org/0000-0003-3634-7615)
- Shuangquan Liu (ORCID: https://orcid.org/0000-0002-2276-367X)
- Wen Dai (ORCID: https://orcid.org/0000-0002-4597-4605)
- Jiayou Luo (ORCID: https://orcid.org/0000-0003-1612-5951)
- Fei Yang (ORCID: https://orcid.org/0000-0001-5687-0556)
- Wei Jia (ORCID: https://orcid.org/0000-0002-3739-8994)
- Zhihang Huang
Institutions
- Central South University (CN)
- Hunan Children's Hospital (CN)
- University of South China (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s12916-025-04461-9
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Natural Science Foundation of China