Multiomic analyses on the contribution of transposable elements to the cis-regulatory landscape of different types of immune cells
Here, we characterized the highly cell-specific profile of TE-derived CREs in different types of human blood immune cells. Integrative analysis further demonstrates the frequent contribution of TEs in creating monocyte enhancers including those specific for human or mouse, and indicates the potential involvement of TEs in mediating species-specific monocyte gene expression.
Authors
- Wenbin Bao (ORCID: https://orcid.org/0000-0001-5486-2253)
- Congrui Zhu (ORCID: https://orcid.org/0000-0002-0905-9979)
- Hairui Fan (ORCID: https://orcid.org/0000-0003-2472-4647)
- Nadezhda E. Vorobyeva (ORCID: https://orcid.org/0000-0003-4293-834X)
- Liming Mao (ORCID: https://orcid.org/0000-0002-9740-820X)
- Jiayao Jiang
- Shuai Chen (ORCID: https://orcid.org/0009-0006-1337-9584)
- Chenxi Li (ORCID: https://orcid.org/0000-0002-3482-4572)
- Yanhua Li (ORCID: https://orcid.org/0000-0001-5584-9376)
- Cui Du (ORCID: https://orcid.org/0000-0002-3060-5698)
- Ming‐an Sun (ORCID: https://orcid.org/0000-0002-4661-3027)
- Juan Yang (ORCID: https://orcid.org/0000-0001-5611-5155)
Institutions
- Nantong University (CN)
- Institute of Gene Biology (RU)
- Ministry of Education (MV)
- Yangzhou University (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s12864-025-12285-3
- Citations
- 1
- Primary Topic
- Chromosomal and Genetic Variations
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- National Natural Science Foundation of China
- Russian Science Foundation
- Yangzhou University
- Priority Academic Program Development of Jiangsu Higher Education Institutions