Crohn's Disease Presenting With Secondary Immunoglobulin A Nephropathy and Cutaneous Vasculitis: Unusual Extraintestinal Manifestations

Crohn's disease (CD) can rarely present with extraintestinal complications involving the renal and cutaneous systems. We describe a 19-year-old man who initially presented with palpable purpura and proteinuria and was diagnosed with leukocytoclastic vasculitis and Immunoglobulin A nephropathy. He subsequently developed fecaluria and abdominal pain, and further evaluation confirmed fistulizing CD with enterovesical fistulae. Initiation of infliximab and azathioprine resulted in clinical improvement and weight gain. This case highlights that CD may exhibit atypical extraintestinal manifestations, such as cutaneous and renal manifestations, which may precede the development of full-blown fistulizing CD. Early recognition and multidisciplinary management are key to prevent complications.

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Journal
ACG Case Reports Journal
Published
2025-11-26
DOI
https://doi.org/10.14309/crj.0000000000001909
Primary Topic
Autoimmune and Inflammatory Disorders
Type
article
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article

Crohn's Disease Presenting With Secondary Immunoglobulin A Nephropathy and Cutaneous Vasculitis: Unusual Extraintestinal Manifestations

Saswati Kar, Hemanta Kumar Nayak, Taraprasad Tripathy, Kamlesh Ahari et al.
ACG Case Reports Journal
Autoimmune and Inflammatory Disorders
article

Crohn's Disease Presenting With Secondary Immunoglobulin A Nephropathy and Cutaneous Vasculitis: Unusual Extraintestinal Manifestations

Saswati Kar, Hemanta Kumar Nayak, Taraprasad Tripathy, Kamlesh Ahari, Shubham Gupta, Susama Patra, Manas Kumar Panigrahi, Subash Chandra Samal
article en

Abstract

Crohn's disease (CD) can rarely present with extraintestinal complications involving the renal and cutaneous systems. We describe a 19-year-old man who initially presented with palpable purpura and proteinuria and was diagnosed with leukocytoclastic vasculitis and Immunoglobulin A nephropathy. He subsequently developed fecaluria and abdominal pain, and further evaluation confirmed fistulizing CD with enterovesical fistulae. Initiation of infliximab and azathioprine resulted in clinical improvement and weight gain. This case highlights that CD may exhibit atypical extraintestinal manifestations, such as cutaneous and renal manifestations, which may precede the development of full-blown fistulizing CD. Early recognition and multidisciplinary management are key to prevent complications.

ACG Case Reports JournalVol. 12(12)
All India Institute of Medical Sciences Bhubaneswar (IN)
Openalex Percentile: Top 52%
Autoimmune and Inflammatory Disorders
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Crohn's Disease Presenting With Secondary Immunoglobulin A Nephropathy and Cutaneous Vasculitis: Unusual Extraintestinal Manifestations — Saswati Kar, Hemanta Kumar Nayak, et al. · ACG Case Reports Journal (2025) | TGRS Research Map | TGRS