Extracellular vesicles from long COVID patients promote RUNX2-mediated cellular stress via dysregulated miR-204 and p53 pathway activation
In conclusions, these findings provide new insights into the role of extracellular vesicles in Long COVID, revealing their involvement in cellular stress and impaired mitochondrial function.
Authors
- Michele Braggio (ORCID: https://orcid.org/0000-0001-7163-6194)
- Anna Pedrinolla (ORCID: https://orcid.org/0000-0001-8888-619X)
- Gaia Giuriato (ORCID: https://orcid.org/0000-0002-8149-9450)
- Adriana Celesia
- Pamela Lorenzi (ORCID: https://orcid.org/0000-0002-4170-3322)
- Andrea Corsi (ORCID: https://orcid.org/0000-0001-7482-3251)
- Mattia Cominacini (ORCID: https://orcid.org/0000-0002-4315-0282)
- Lucio Barile (ORCID: https://orcid.org/0000-0002-5827-0439)
- Federico Schena (ORCID: https://orcid.org/0000-0002-2052-5117)
- Massimo Donadelli (ORCID: https://orcid.org/0000-0001-9224-9230)
- Ernesto Crisafulli (ORCID: https://orcid.org/0000-0001-7298-7084)
- Luca Dalle Carbonare (ORCID: https://orcid.org/0000-0003-3263-6671)
- Massimo Venturelli (ORCID: https://orcid.org/0000-0002-2469-8787)
- Donato Zipeto (ORCID: https://orcid.org/0000-0002-2168-4144)
- Monica Mottes (ORCID: https://orcid.org/0000-0002-7390-2246)
- Arianna Minoia (ORCID: https://orcid.org/0000-0003-4610-1168)
- Alessandra Fiore (ORCID: https://orcid.org/0000-0003-2070-6046)
- Massimiliano Perduca (ORCID: https://orcid.org/0000-0001-8291-0523)
- Daniele Guardavaccaro (ORCID: https://orcid.org/0000-0002-4517-1765)
- Francesca Cristiana Piritore (ORCID: https://orcid.org/0009-0003-2096-9441)
- Sharazed Zouari (ORCID: https://orcid.org/0009-0007-7281-6024)
- Mirko Meneghel
- Laura Guerricchio (ORCID: https://orcid.org/0009-0004-3010-1985)
- Salvatore Calogero Gaglio (ORCID: https://orcid.org/0000-0002-8938-0745)
- Maria Teresa Valenti (ORCID: https://orcid.org/0000-0003-1166-8033)
- Maria Grazia Romanelli (ORCID: https://orcid.org/0000-0002-7360-1195)
- Kevin Dervishi
Institutions
- University of Verona (IT)
- Azienda Ospedaliera Universitaria Integrata Verona (IT)
- Ente Ospedaliero Cantonale (CH)
- Università della Svizzera italiana (CH)
- University of Genoa (IT)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s12964-025-02502-7
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Università degli Studi di Verona