Clinical and Pathological Spectrum of Acromegaly: Distinguishing GH PitNETs, Mammosomatotrophs, and Mixed Tumors
These findings highlight the heterogeneity within GH&PRL-PitNETs, including silent PRL-positive GH PitNETs. Our data suggest mixed-SL tumors may be less responsive to somatostatin receptor ligands, emphasizing the need for tailored strategies based on tumor subtype and receptor profile.
Authors
- Rebeca Martínez‐Hernández (ORCID: https://orcid.org/0000-0003-2479-1882)
- Ana Serrano-Somavilla
- Miguel Sampedro‐Núñez (ORCID: https://orcid.org/0000-0002-0089-4046)
- Fernando Sebastián‐Valles (ORCID: https://orcid.org/0000-0002-4127-0483)
- J.F. Alén
- Mónica Marazuela (ORCID: https://orcid.org/0000-0003-1158-9618)
- Marta Araujo‐Castro (ORCID: https://orcid.org/0000-0002-0519-0072)
- Pablo Sacristán-Gómez (ORCID: https://orcid.org/0000-0003-3276-100X)
- Manel Puig‐Domingo (ORCID: https://orcid.org/0000-0002-6744-7195)
- Betina Biagetti (ORCID: https://orcid.org/0000-0002-8837-4343)
- Ignacio Ruz‐Caracuel (ORCID: https://orcid.org/0000-0002-2298-4683)
- Nuria Sánchez de la Blanca (ORCID: https://orcid.org/0009-0004-2188-0032)
- Víctor Navas-Moreno (ORCID: https://orcid.org/0009-0001-8138-4178)
- Fernando F Méndez-García
Institutions
- Hebron University (PS)
- Vall d'Hebron Institut de Recerca (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital Universitario de La Princesa (ES)
- Hospital Universitari Germans Trias i Pujol (ES)
- Hospital Universitario Ramón y Cajal (ES)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1210/clinem/dgaf634
- Citations
- 1
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.29