Stem cell specification and niche formation in developing incisor require actomyosin forces
This mechanical confinement likely plays an important role in maintaining their stemness until the niche is functionally and structurally established. Partial or complete disruption of the actomyosin network disables the clustering of Sox2-expressing cells, potentially triggering their premature differentiation, and ultimately leads to impaired formation of the functional stem cell niche and abnormal growth of the incisor.
Authors
- L. Evers
- Satu-Marja Myllymäki (ORCID: https://orcid.org/0000-0003-0521-5062)
- Irma Thesleff
- Maria Jussila (ORCID: https://orcid.org/0000-0002-6214-999X)
- Emma Juuri (ORCID: https://orcid.org/0000-0003-3252-9323)
- Paul Gueguen (ORCID: https://orcid.org/0000-0003-2930-6073)
- Anamaria Balic (ORCID: https://orcid.org/0000-0001-6796-1197)
- Mina Mina
- Yasmin Mohtadi Hamadani
Institutions
- University of Helsinki (FI)
- University of Zurich (CH)
- Helsinki Institute of Physics (FI)
- Helsinki University Hospital (FI)
- ETH Zurich (CH)
- UConn Health (US)
Publication Details
- Journal
- Stem Cells
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1093/stmcls/sxaf074
- Primary Topic
- dental development and anomalies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Helsingin Yliopisto
- Universität Zürich