Exploratory functional and quality of life outcomes with daily consumption of the ketone ester bis-octanoyl (R)-1,3-butanediol in healthy older adults: a randomized, parallel arm, double-blind, placebo-controlled study
Daily ingestion of 25 g of KE did not affect exploratory functional or quality-of-life end points in this pilot cohort of healthy older adults. Future work will address these endpoints as primary and secondary outcomes in a larger trial of pre-frail older adults.
Authors
- Tyler A. Mansfield (ORCID: https://orcid.org/0009-0009-9573-3007)
- Thelma Y. Garcia (ORCID: https://orcid.org/0009-0007-6752-8570)
- Peggy M. Cawthon (ORCID: https://orcid.org/0000-0003-4938-9478)
- James B. Johnson (ORCID: https://orcid.org/0000-0002-0539-0998)
- Brianna J. Stubbs (ORCID: https://orcid.org/0000-0001-9566-9134)
- Laura E. Crotty Alexander (ORCID: https://orcid.org/0000-0002-5091-2660)
- Michi Yukawa (ORCID: https://orcid.org/0000-0002-5805-5464)
- Anne B. Newman (ORCID: https://orcid.org/0000-0002-0106-1150)
- John C. Newman (ORCID: https://orcid.org/0000-0002-8455-0100)
- Chatura Senadheera
- Sawyer Peralta (ORCID: https://orcid.org/0009-0002-8432-3036)
- Jamie Kurtzig
- James T Yurkovich
- Stephanie Roa Diaz
- Jennifer Morris
- Wendie Silverman-Martin
- Elizabeth B Stephens
- Bernadette Fernando
Institutions
- San Francisco VA Medical Center (US)
- Buck Institute for Research on Aging (US)
- University of Pittsburgh (US)
- California Pacific Medical Center (US)
- University of California San Francisco Medical Center (US)
- Marin Endocrine Care and Research (US)
- ProNAi Therapeutics (United States) (US)
Publication Details
- Journal
- The Journal of Frailty & Aging
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1016/j.tjfa.2025.100106
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00