The impact of adherence on colorectal cancer screening cost-effectiveness: A modeling study
Improving screening participation could enhance health benefits and cost-efficiency in CRC screening. Questionnaire-based risk assessment combined with FIT was a cost-effective strategy in China, whereas non-invasive biomarker-based methods require cost reduction and higher uptake to justify adoption. These findings provide evidence for policymakers to optimize CRC screening programs.
Authors
- Lingbin Du (ORCID: https://orcid.org/0000-0002-1992-7784)
- Ni Li (ORCID: https://orcid.org/0000-0001-5530-7745)
- Zilin Luo (ORCID: https://orcid.org/0000-0001-5071-1423)
- Dong Hang (ORCID: https://orcid.org/0000-0001-6944-0459)
- Weimiao Wu (ORCID: https://orcid.org/0000-0001-6348-619X)
- Yongjie Xu (ORCID: https://orcid.org/0000-0001-8417-3168)
- Yadi Zheng (ORCID: https://orcid.org/0000-0002-9849-0997)
- Xuesi Dong (ORCID: https://orcid.org/0000-0003-2986-7866)
- Wei Cao (ORCID: https://orcid.org/0000-0001-9163-5711)
- Le Wang (ORCID: https://orcid.org/0000-0002-6142-7134)
- Fei Wang (ORCID: https://orcid.org/0000-0002-0947-008X)
- Jiaxin Xie (ORCID: https://orcid.org/0000-0002-6352-1589)
- Zeming Guo
- Chenran Wang (ORCID: https://orcid.org/0000-0002-4202-126X)
- Xiaoyue Shi (ORCID: https://orcid.org/0000-0001-7472-400X)
- Xiaolu Chen (ORCID: https://orcid.org/0009-0002-8472-0138)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Zhejiang Cancer Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- PLoS Medicine
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1371/journal.pmed.1004807
- Citations
- 2
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 2.09