TNFAIP3 alleviates cerebral ischemia-reperfusion injury by inhibiting M1 microglia polarization via deubiquitination of RACK1
The present findings indicate that TNFAIP3 inhibits M1 microglial polarization via deubiquitination of RACK1 after CIRI, RACK1 exerts its effects through NF-κB.
Authors
- Junchao Zhu (ORCID: https://orcid.org/0000-0001-7650-1811)
- Shixuan Liu (ORCID: https://orcid.org/0000-0003-4972-415X)
- Wenya Bai (ORCID: https://orcid.org/0000-0001-5329-2527)
- Xuelian Li (ORCID: https://orcid.org/0000-0001-9043-8580)
- Huan Jiang (ORCID: https://orcid.org/0000-0003-2597-4576)
- Jianlin Shao (ORCID: https://orcid.org/0000-0001-9878-7064)
- Guilin Zhou (ORCID: https://orcid.org/0000-0003-4909-2834)
Institutions
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1371/journal.pone.0337601
- Primary Topic
- NF-κB Signaling Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00