A Systematic Review Evaluating Estimated GFR Performance in South Asian Populations
eGFR equation accuracy in South Asians is suboptimal, consistently below the accepted clinical P30 threshold of 75%. eGFR<sub>CysC</sub> equations had reduced bias compared with eGFR<sub>Cr</sub> or eGFR<sub>Cr-CysC</sub>; however, accuracy was better with eGFR<sub>Cr-CysC</sub>. Emerging equations, such as the CKD-EPI-Pakistan variant and European Kidney Function Consortium (EKFC) equations warrant further investigation in diverse South Asian cohorts with population-specific calibration.
Authors
- Kate Bramham (ORCID: https://orcid.org/0000-0002-6272-7921)
- Alexander Sarnowski (ORCID: https://orcid.org/0000-0002-4579-6028)
- Pierre Delanaye (ORCID: https://orcid.org/0000-0002-1480-5761)
- Ayush Sinha (ORCID: https://orcid.org/0000-0001-5580-3028)
- Kathryn V. Dalrymple (ORCID: https://orcid.org/0000-0003-0958-6725)
- Rouvick Gama (ORCID: https://orcid.org/0000-0003-0292-7582)
Institutions
- University of Liège (BE)
- King's College London (GB)
- University of Oxford (GB)
- Royal Surrey NHS Foundation Trust (GB)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-11-16
- DOI
- https://doi.org/10.1016/j.ekir.2025.11.004
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00