Expansion of a distinct cytotoxic CD4 TFH-cell cluster in lymph nodes of patients with complicated common variable immunodeficiency
Our study reports for the first time that the type 1 polarization in lymph nodes of patients with CVIDc is associated with an expansion of a distinct cytotoxic CD4 T<sub>FH</sub>-cell cluster within GCs, which is only poorly reflected in peripheral blood. Because a detrimental role of these cells has been implied in the context of autoimmunity and chronic infection, further investigations are required to explore their role in the GC failure and immune dysregulation in patients with CVID.
Authors
- Kathryn Payne (ORCID: https://orcid.org/0000-0003-3311-5210)
- Ke Meng (ORCID: https://orcid.org/0000-0002-2460-4728)
- Alexandra Emilia Schlaak (ORCID: https://orcid.org/0000-0001-5892-9224)
- Baerbel Keller (ORCID: https://orcid.org/0000-0002-1491-6971)
- Maximilian Seidl (ORCID: https://orcid.org/0000-0002-5559-4980)
- Katja Gräwe
- Melanie Boerries (ORCID: https://orcid.org/0000-0002-3670-0602)
- Oliver Hausmann (ORCID: https://orcid.org/0000-0002-6599-841X)
- Klaus Warnatz (ORCID: https://orcid.org/0000-0002-1172-865X)
- Manuel Rogg (ORCID: https://orcid.org/0000-0002-6658-9159)
- Bertram Bengsch (ORCID: https://orcid.org/0000-0003-2552-740X)
- Konrad Aumann (ORCID: https://orcid.org/0000-0001-8178-1571)
- Sigune Goldacker
- Michelle Shabani
- Till F. Jakob (ORCID: https://orcid.org/0000-0001-7891-0651)
- Vladimı́r Beneš (ORCID: https://orcid.org/0000-0002-0352-2547)
- Geoffroy Andrieux (ORCID: https://orcid.org/0000-0002-5389-9481)
- Susanne Unger (ORCID: https://orcid.org/0000-0001-6916-7544)
- Tobias Boettler (ORCID: https://orcid.org/0000-0002-1195-055X)
- Konrad Kurowski (ORCID: https://orcid.org/0009-0009-0448-7999)
- Christoph Schell (ORCID: https://orcid.org/0000-0001-5344-624X)
- Christoph B. Geier (ORCID: https://orcid.org/0000-0003-4353-8663)
- Jan Provazník (ORCID: https://orcid.org/0000-0003-1104-1169)
- Adam Klocperk (ORCID: https://orcid.org/0000-0002-1526-4557)
- Victoria N. Cousin
- David Friedmann (ORCID: https://orcid.org/0000-0003-3264-7426)
- Jens Pfeiffer
- Peter Anhut
Institutions
- University of Freiburg (DE)
- University Medical Center Freiburg (DE)
- Düsseldorf University Hospital (DE)
- Hirslanden Klinik St. Anna (CH)
- European Molecular Biology Laboratory (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1016/j.jaci.2025.09.032
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00