Microbiome Mediated Immune Crosstalk on the Gut-Thyroid Axis in Autoimmune Thyroid Disease

Despite largely associative human evidence, converging mechanistic findings highlight the gut microbiota as a modifiable contributor to thyroid autoimmunity. Future priorities include clarifying causality, identifying keystone microbial taxa and metabolites, and establishing standardized interventional frameworks to facilitate translation into endocrine practice.

Authors

Shantanu Baral
Ning Sun
Hongting Li
Lijun Fu (ORCID: https://orcid.org/0000-0003-2501-3740)
Xinguang Qiu (ORCID: https://orcid.org/0000-0002-3816-1745)
Feihong Ji
Fitrat Habibullah
Mubeen Hussein Arawker

Institutions

Northern Jiangsu People's Hospital (CN)
First Affiliated Hospital of Zhengzhou University (CN)

Publication Details

Journal: Immunological Investigations
Published: 2025-11-26
DOI: https://doi.org/10.1080/08820139.2025.2593335
Primary Topic: Gut microbiota and health
Type: article
Field-Weighted Citation Impact: 0.00

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article

Microbiome Mediated Immune Crosstalk on the Gut-Thyroid Axis in Autoimmune Thyroid Disease

Shantanu Baral, Ning Sun, Hongting Li, Lijun Fu et al.

Nov 26, 2025

Immunological Investigations

Gut microbiota and health

article

Microbiome Mediated Immune Crosstalk on the Gut-Thyroid Axis in Autoimmune Thyroid Disease

Shantanu Baral, Ning Sun, Hongting Li, Lijun Fu, Xinguang Qiu, Feihong Ji, Fitrat Habibullah, Mubeen Hussein Arawker

November 26, 2025article en

Abstract

Despite largely associative human evidence, converging mechanistic findings highlight the gut microbiota as a modifiable contributor to thyroid autoimmunity. Future priorities include clarifying causality, identifying keystone microbial taxa and metabolites, and establishing standardized interventional frameworks to facilitate translation into endocrine practice.

Immunological InvestigationsVol. 55(2)

Northern Jiangsu People's Hospital (CN), First Affiliated Hospital of Zhengzhou University (CN)

Openalex Percentile: Top 67%

Gut microbiota and health

DOI Source OpenAlex

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