Maternal Use of Integrase Strand Transfer Inhibitors During Pregnancy and Infant Neurodevelopment
In this cohort study, infants exposed in utero to INSTI-based ART regimens had mean neurodevelopmental scores similar to those for infants exposed to PI-based regimens but lower than those for infants exposed to NNRTI-based regimens, particularly when their mothers initiated ART after conception. Notably, adjusted mean cognitive domain scores for INSTI-exposed infants were close to the expected population mean of 100, while NNRTI-exposed infants scored 4 to 5 points above the population mean. These findings support continued inclusion of INSTIs in first-line regimens for pregnant women with HIV.
Authors
- Yanling Huo
- Ellen G. Chadwick
- Stephen A. Spector (ORCID: https://orcid.org/0000-0002-1882-4855)
- Janna B. Oetting (ORCID: https://orcid.org/0000-0003-3092-8320)
- Paige L. Williams (ORCID: https://orcid.org/0000-0002-7160-574X)
- Patricia A. Garvie (ORCID: https://orcid.org/0000-0003-4703-0808)
- Renee Smith
- Martha Boahene
- Lisa E. Mash
Institutions
- Northwestern University (US)
- Louisiana State University (US)
- Harvard University (US)
- University of Illinois Chicago (US)
- Rady Children's Hospital-San Diego (US)
- Cancer Research And Biostatistics (US)
- Children's Diagnostic & Treatment Center (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.45652
- Citations
- 1
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.40