Insulin resistance as a mediator of physical activity's effects on beta-amyloid accumulation and tau phosphorylation: A scoping review
Exercise can simultaneously impact insulin resistance and Alzheimer's disease pathology in animal models. Results from human research are limited, and no robust evaluation of the potential mediating role of insulin resistance in the physical activity - Aβ or tau relationship exists. Future research should focus on identifying the mediating pathways that may link physical activity to biomarkers of Alzheimer's disease.
Authors
- Kirk I. Erickson (ORCID: https://orcid.org/0000-0001-8736-981X)
- Giuseppe Verdile (ORCID: https://orcid.org/0000-0003-2475-0124)
- Hamid R. Sohrabi (ORCID: https://orcid.org/0000-0001-8017-8682)
- Stephanie R. Rainey‐Smith (ORCID: https://orcid.org/0000-0001-7328-9624)
- Belinda M. Brown (ORCID: https://orcid.org/0000-0001-7927-2540)
- Michael G Slee
- Joanne Scotney
Institutions
- Edith Cowan University (AU)
- Murdoch University (AU)
- Curtin University (AU)
- Translational Research Institute for Metabolism and Diabetes (US)
- Avenir Health (US)
Publication Details
- Journal
- Ageing Research Reviews
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1016/j.arr.2025.102956
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00