Tirabrutinib–anthracycline interactions in the brain tumor microenvironment: a focus on metabolic inactivation and resistance
Our <i>in vitro</i> data demonstrate that tirabrutinib influences daunorubicin pharmacodynamics by targeting both metabolic and transport pathways. However, Chou-Talalay analysis highlights the importance of appropriate dosing to achieve therapeutic synergy in combination regimens.
Authors
- Ivona Špringrová
- Lenka Laštovičková (ORCID: https://orcid.org/0000-0003-4070-4152)
- Lucie Čermáková (ORCID: https://orcid.org/0000-0002-2322-4096)
- Vladimı́r Wsól (ORCID: https://orcid.org/0000-0003-3745-7648)
- Eva Novotná (ORCID: https://orcid.org/0000-0001-9365-3163)
- Alessandra Bonamore (ORCID: https://orcid.org/0000-0002-3940-4657)
- Alberto Macone (ORCID: https://orcid.org/0000-0003-0455-1400)
- Magdaléna Kašparová
- Nikola Lebeková
- Silvia Chmurová
Institutions
- Charles University (CZ)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Expert Opinion on Drug Metabolism & Toxicology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1080/17425255.2025.2595661
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00