Simultaneous Diagnosis of Allergic Bronchopulmonary Aspergillosis and <i>Mycobacterium Avium</i> Complex Lung Disease in a Patient with Ankylosing Spondylitis Treated with Adalimumab
We report the case of a 56-year-old male with ankylosing spondylitis who developed allergic bronchopulmonary aspergillosis (ABPA) and Mycobacterium avium complex (MAC) lung disease 3 months after the initiation of adalimumab treatment. The patient presented with a wet cough and nocturnal wheezing. Chest computed tomography revealed bronchiectasis, mucus with a high-attenuation pattern, and granular shadows in the right upper lobe. Simultaneous ABPA and MAC lung diseases were diagnosed on the basis of laboratory tests, bronchoscopic findings, and mucus plug cultures. The patient was successfully treated with oral prednisolone and itraconazole for ABPA and antimycobacterial drugs for MAC lung disease without recurrence for 7 years.
Authors
- Makoto Osawa (ORCID: https://orcid.org/0000-0002-7661-2666)
- Reiko Tanaka (ORCID: https://orcid.org/0000-0002-0769-9382)
- Wataru Shigemori
- Keiko Narumiya
- Shinya Yokoe
- Akio Yamazaki (ORCID: https://orcid.org/0000-0001-8926-5336)
- Tomoko Iriyama (ORCID: https://orcid.org/0009-0001-5930-8881)
- Toshio Horiuchi
- Daisuke Kinose (ORCID: https://orcid.org/0000-0003-1182-5844)
- Ruriko Yukimura
- Masafumi Yamaguchi (ORCID: https://orcid.org/0000-0002-0369-324X)
- Yoko Tsunoda
- Yasutaka Nakano (ORCID: https://orcid.org/0000-0001-7516-8690)
- Hiroaki Nakagawa (ORCID: https://orcid.org/0000-0003-3830-765X)
- Emiko Ogawa (ORCID: https://orcid.org/0000-0002-2507-7499)
- Aya Ooka
- Yasumitsu Ueki
- Miho Goto
Institutions
- Shiga University of Medical Science (JP)
- Shiga University of Medical Science Hospital (JP)
Publication Details
- Journal
- Respiratory Endoscopy
- Published
- 2025-11-26
- DOI
- https://doi.org/10.58585/respend.2025-0017
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00