A Rare Case of Amyloid Goiter Suspected to be Malignant on Imaging Findings

A 67-year-old man was diagnosed with Hashimoto's thyroiditis, and replacement therapy with levothyroxine was initiated. Ten years later, although the patient was euthyroid, ultrasonography showed an increase in goiter size and a significant decrease in overall echogenicity with scattered high-echo areas. Computed tomography revealed diffuse low-density areas with no contrast effect in the thyroid parenchyma and partial high-density areas, indicating possible malignancy. However, a core needle biopsy revealed an amyloid light-chain (AL) κ-type amyloid goiter. Because serum immunoprecipitation electrophoresis showed IgG κ-type M-protein, the diagnosis was secondary amyloidosis. It is important to consider amyloid goiter with imaging findings, as in this case.

Authors

Institutions

Publication Details

Journal
Internal Medicine
Published
2025-11-26
DOI
https://doi.org/10.2169/internalmedicine.5426-25
Primary Topic
Amyloidosis: Diagnosis, Treatment, Outcomes
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

A Rare Case of Amyloid Goiter Suspected to be Malignant on Imaging Findings

Ryohei Katoh, Ai Yoshihara, Kiminori Sugino, Masahiro Ichikawa et al.
Internal Medicine
Amyloidosis: Diagnosis, Treatment, Outcomes
article

A Rare Case of Amyloid Goiter Suspected to be Malignant on Imaging Findings

Ryohei Katoh, Ai Yoshihara, Kiminori Sugino, Masahiro Ichikawa, Natsuko Watanabe, Nami Suzuki, Miho Fukushita, Rei Hirose, Masakazu Koshibu, Toshino Suzuki, Jaeduk Yoshimura Noh, Koichi Ito, Tatsuya Iida, Masako Matsumoto
article en

Abstract

A 67-year-old man was diagnosed with Hashimoto's thyroiditis, and replacement therapy with levothyroxine was initiated. Ten years later, although the patient was euthyroid, ultrasonography showed an increase in goiter size and a significant decrease in overall echogenicity with scattered high-echo areas. Computed tomography revealed diffuse low-density areas with no contrast effect in the thyroid parenchyma and partial high-density areas, indicating possible malignancy. However, a core needle biopsy revealed an amyloid light-chain (AL) κ-type amyloid goiter. Because serum immunoprecipitation electrophoresis showed IgG κ-type M-protein, the diagnosis was secondary amyloidosis. It is important to consider amyloid goiter with imaging findings, as in this case.

Internal Medicine
Ito Hospital (JP)
Openalex Percentile: Top 67%
Amyloidosis: Diagnosis, Treatment, Outcomes
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

A Rare Case of Amyloid Goiter Suspected to be Malignant on Imaging Findings — Ryohei Katoh, Ai Yoshihara, et al. · Internal Medicine (2025) | TGRS Research Map | TGRS