Vascular Health and Early Atherosclerosis in Childhood Cancer Survivors: Reassuring Findings From Comprehensive Noninvasive Assessment
Vascular markers of early atherosclerosis did not significantly differ between CCS and controls. Late CCS demonstrated mild vascular alteration compared with early CCS, although not compared with the healthy population. Whether these represent subclinical precursors of atherosclerosis needs further study. Routine vascular surveillance in this population is not clearly warranted.
Authors
- Kyle Runeckles (ORCID: https://orcid.org/0000-0002-6750-4700)
- Emmanuelle Fournier
- Alice Pozza (ORCID: https://orcid.org/0009-0003-4799-5551)
- Luc Mertens (ORCID: https://orcid.org/0000-0001-7308-1268)
- Paul Craig Nathan (ORCID: https://orcid.org/0000-0003-0334-0871)
- Marisa Signorile
- Emily Lam (ORCID: https://orcid.org/0000-0002-1931-2691)
- Chun‐Po Steve Fan (ORCID: https://orcid.org/0000-0002-1278-0118)
- Mark K. Friedberg (ORCID: https://orcid.org/0000-0002-4108-5560)
- Wei Hui (ORCID: https://orcid.org/0000-0002-2135-7741)
- Raphael Joye (ORCID: https://orcid.org/0000-0002-2201-0096)
- B. McCrindle
Institutions
- University of Toronto (CA)
- Hospital for Sick Children (CA)
- Ted Rogers Centre for Heart Research (CA)
- SickKids Foundation (CA)
Publication Details
- Journal
- JACC Advances
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1016/j.jacadv.2025.102349
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00