Cytological Features of Metastatic Clear Cell Renal Cell Carcinoma Diagnosed on Cytology: A Single-Center Experience with Literature Review

Key markers such as PAX8, CD10, and RCCma were critical in confirming renal origin and differentiating ccRCC from morphologically similar neoplasms in each organ. FNA cytology, corroborated by focused immunocytochemistry, plays a key role in diagnosing metastatic ccRCC, particularly when the presentation is uncommon or the primary tumor is hidden. This integrated method supports effective clinical management, avoiding unnecessary surgery in cases that may benefit from systemic therapy.