Osteoradionecrosis After Intensity-Modulated Radiation Therapy or Proton Therapy in Oropharyngeal Carcinoma
In this large, relatively homogeneous cohort of patients with OPSCC, proton therapy was associated with a higher rate of ORN compared with IMRT, particularly in the definitive setting, although high-grade ORN remained uncommon across both modalities. These retrospective findings should be considered exploratory and underscore the need for future hypothesis-driven studies to refine dose constraints and optimize treatment planning to mitigate ORN risk among patients with OPSCC.
Authors
- Annu Singh (ORCID: https://orcid.org/0000-0001-7066-4492)
- SaeHee K. Yom
- Sean Matthew McBride (ORCID: https://orcid.org/0000-0002-9676-1669)
- Daphna Y. Gelblum (ORCID: https://orcid.org/0000-0001-7211-6246)
- Kevin Sine
- Cherry L. Estilo (ORCID: https://orcid.org/0000-0003-2802-0671)
- Jennifer R. Cracchiolo (ORCID: https://orcid.org/0000-0003-4496-906X)
- Kaveh Zakeri (ORCID: https://orcid.org/0000-0003-3921-480X)
- Nadeem Riaz (ORCID: https://orcid.org/0000-0001-9873-5862)
- Haibo Lin (ORCID: https://orcid.org/0000-0001-7476-0967)
- Yao Yu (ORCID: https://orcid.org/0000-0002-2814-4482)
- Alan Loh Ho (ORCID: https://orcid.org/0000-0002-6885-3742)
- Nancy Y. Lee (ORCID: https://orcid.org/0000-0003-3044-9522)
- Edward Christopher Dee (ORCID: https://orcid.org/0000-0001-6119-0889)
- Teeradon Treechairusame (ORCID: https://orcid.org/0000-0002-2731-9500)
- Joseph M. Huryn (ORCID: https://orcid.org/0000-0002-7130-6264)
- Eric Jeffrey Sherman (ORCID: https://orcid.org/0000-0002-4960-4783)
- Marc A. Cohen (ORCID: https://orcid.org/0000-0002-6104-7967)
- Richard J. Wong (ORCID: https://orcid.org/0000-0001-6259-7314)
- C. Jillian Tsai (ORCID: https://orcid.org/0009-0004-8051-0787)
- Achraf A. Shamseddine (ORCID: https://orcid.org/0000-0003-3686-5850)
- Jung Julie Kang (ORCID: https://orcid.org/0000-0001-9773-5481)
- Dennis Mah (ORCID: https://orcid.org/0000-0003-3644-0828)
- James O. Suggitt
- Zhigang Zhang (ORCID: https://orcid.org/0000-0002-4974-5850)
- Yingzhi Wu
- Fan Yang (ORCID: https://orcid.org/0000-0002-8227-5272)
- Linda Chen (ORCID: https://orcid.org/0000-0001-7078-163X)
- Andy Shim
- Ian Ganly
- Elizabeth Silverio Polanco
- Arya Honawar
Institutions
- University Health Network (CA)
- Siriraj Hospital (TH)
- Memorial Sloan Kettering Cancer Center (US)
- Cornell University (US)
- Mahidol University (TH)
- Princess Margaret Cancer Centre (CA)
- Yale University (US)
- Presbyterian Hospital (US)
- New York Proton Center (US)
- ProCure (United States) (US)
- Michigan State University (US)
Publication Details
- Journal
- JAMA Otolaryngology–Head & Neck Surgery
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1001/jamaoto.2025.4179
- Citations
- 3
- Primary Topic
- Oral health in cancer treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.56