The Role of Fibrosis in Androgenetic Alopecia: Mechanisms and Implications
Perifollicular fibrosis is integral to AGA progression and may underlie incomplete treatment responses. Dermoscopic signs such as perifollicular hyperpigmentation and whitish perifollicular structures may correlate with histologic fibrosis and merit validation. Pathway-directed anti-fibrotic agents targeting TGF-β and Wnt/Notch show anti-fibrotic activity in other organs but require AGA-specific testing.
Authors
- Tongyao Chen
- Xiaoxia Ding (ORCID: https://orcid.org/0000-0002-2517-7166)
- Y Xi
- Le‐Wei Li (ORCID: https://orcid.org/0000-0002-0551-0259)
- Ming‐Yi Lin (ORCID: https://orcid.org/0000-0001-7264-0902)
- Yibin Fan (ORCID: https://orcid.org/0000-0003-4201-8498)
- Yuqi Chen (ORCID: https://orcid.org/0000-0001-8132-1225)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Skin Appendage Disorders
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1159/000549748
- Primary Topic
- Hair Growth and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00