Corticosteroids, rifampicin and LMWH impact plasma aMMP-8 and TIMP-1 and aMMP-8/TIMP-1 molar ratio in methicillin-sensitive Staphylococcus aureus bacteremia
Corticosteroids, rifampicin, and LMWH may elevate aMMP-8 and aMMP-8/TIMP-1 levels in MS-SAB; however, the prognostic value of aMMP-8/TIMP-1 is not disrupted. Clinicians should consider the presence of corticosteroids, rifampicin, and LMWH when applying MMPs as biomarkers for risk stratification in patients with MS-SAB.
Authors
- Eeva Ruotsalainen (ORCID: https://orcid.org/0000-0001-8747-2972)
- A Järvinen (ORCID: https://orcid.org/0009-0005-2487-5113)
- Erik Forsblom (ORCID: https://orcid.org/0000-0001-9220-8826)
- Taina Tervahartiala (ORCID: https://orcid.org/0000-0001-8817-896X)
- Timo Sorsa (ORCID: https://orcid.org/0000-0001-7914-3052)
- M Kivelä-Rajamäki
Institutions
- University of Helsinki (FI)
- Helsinki University Hospital (FI)
- Hospital District of Helsinki and Uusimaa (FI)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1016/j.ijid.2025.108261
- Citations
- 1
- Primary Topic
- Neonatal and Maternal Infections
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Medicinska Understödsföreningen Liv och Hälsa