Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants

Collectively, the 17 (9 with short and 8 with long sleep) loci provided evidence into the biomolecular mechanisms underlying sleep-associated lipid changes, including potential involvement of the vitamin D receptor pathway. Collectively, these findings may contribute developing novel interventions for treating dyslipidemia in people with sleep disturbances.

Authors

Institutions

Publication Details

Journal
Atherosclerosis
Published
2025-11-26
DOI
https://doi.org/10.1016/j.atherosclerosis.2025.120603
Citations
1
Primary Topic
Sleep and related disorders
Type
article
Field-Weighted Citation Impact
2.12

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants

Natasha L. Pacheco, Peter W.F. Wilson, Traci M. Bartz, Lisa de las Fuentes et al.
1 citations
Atherosclerosis
Sleep and related disorders
2.12
article

Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants

Natasha L. Pacheco, Peter W.F. Wilson, Traci M. Bartz, Lisa de las Fuentes, Clint L. Miller, Todd L. Edwards, John L. Morrison, Patricia A. Peyser, Takahisa Kawaguchi, Zekai Chen, Mart Kals, Thomas C Russ, Cashell E. Jaquish, Xiaofeng Zhu, Themistocles L. Assimes, Annemarie I. Luik, Ilja M. Nolte, Songmi Lee, Jill M. Norris, Han Chen, J. Michael Gaziano, Renata L. Riha, Yasuharu Tabara, Hannah G. Polikowsky, Christophe Lefèvre, Botong Shen, Raymond Noordam, Pramod Anugu, Zhijie Huang, Qin Hui, Patricia B. Munroe, Changwei Li, Ileana De Anda‐Duran, Rui Xia, Lauren E. Petty, Susan P. Fisher‐Hoch, D. C. Rao, Jennifer Elizabeth Below, Amy R. Bentley, Sarah E. Harris, Gregorio V. Linchangco, Tamar Sofer, James B. Meigs, Mary F. Feitosa, M. Arfan Ikram, Dina Vojinović, Alisa K. Manning, Tariq Faquih, Hans Jörgen Grabe, Ayush Giri, Edward Ruiz-Narváez, Yan V. Sun, Matthias Nauck, Massimo Mangino, Kristin L. Young, Susan Redline, Kenneth E. Westerman, Laura M. Raffield, Maris Teder‐Laving, Tanika N. Kelly, Kelly Cho, Peter J. van der Most, Lydia Bazzano, Carrie A Karvonen-Gutierrez, Joseph B. McCormick, Laura D. Baker, Yuri Milaneschi, Christie Mitchell Ballantyne, Pavithra Nagarajan, John Attia, James E. Hixson, Quan Sun, Paul S. de Vries, Debbie A. Lawlor, Brenda W.J.H. Penninx, Tuomas O. Kilpeläinen, Jennifer A. Smith, Md Abu Yusuf Ansari, Michelle M. Hood, Kari E. North, Mohsen Ghanbari, Wenyi Wang, Sami Heikkinen, Stephen S. Rich, Sioḃán D. Harlow, Simon R. Cox, Michael R. Brown, Stefan Weiß, Michael Y. Tsai, Latchezar Dimitrov, Serena C. Houghton, Henry J. Lin, Wei Zhao, Cristina Menni, Rima Destya Triatin, Ko Willems van Dijk, Varun Rao, Aroon D. Hingorani, Ching‐Ti Liu, Yuk‐Lam Ho, Hung‐Hsin Chen, Sina A. Gharib, Karen Schwander, C. Charles Gu, Lynne E. Wagenknecht, Wei Chen, Qian Yang, Xiuqing Guo, Mariaelisa Graff, Fumihiko Matsuda, Jie Yao, Myriam Fornage, Eric Boerwinkle, Xu Hanfei, Ruiyuan Zhang, Kent D. Taylor, Jingxian Tang, Nora Franceschini, Wanying Zhu, Hugues Aschard, Ervin R. Fox, Heming Wang, Henry Völzke, Alan B Zonderman, Yujie Wang, Harold Snieder, Alanna C. Morrison, Michael A. Province, Timo A Lakka, Bruce M. Psaty, Colleen M. Sitlani, Reedik Mägi, Anh Do, Rainer Rauramaa, Tim D. Spector, Pirjo Komulainen, Brain Cade, Jintao Ma, Aldi T. Kraja, Yii-Der Ida Chen, Michelle Evans, Jiang He, Jeffrey R. O’Connel, W. James Gauderman, Thomas Winkler
article en
1 citations

Abstract

Collectively, the 17 (9 with short and 8 with long sleep) loci provided evidence into the biomolecular mechanisms underlying sleep-associated lipid changes, including potential involvement of the vitamin D receptor pathway. Collectively, these findings may contribute developing novel interventions for treating dyslipidemia in people with sleep disturbances.

AtherosclerosisVol. 412
Broad Institute (US), Boston University (US), University of North Carolina at Chapel Hill (US), Tulane University (US), University of Southern California (US), Tufts University (US), University of Maryland, Baltimore (US), Brigham and Women's Hospital (US), National Institutes of Health (US), University of Minnesota (US), Beth Israel Deaconess Medical Center (US), NHS Lothian (GB), University Medical Center Groningen (NL), Emory University (US), Colorado School of Public Health (US), Institut Pasteur (FR), Queen Mary University of London (GB), University of Groningen (NL), University of Eastern Finland (FI), Baylor College of Medicine (US), King's College London (GB), University of Washington (US), Washington University in St. Louis (US), Université Paris Cité (FR), VA Palo Alto Health Care System (US), Kyoto University (JP), University of Michigan (US), Universitätsmedizin Greifswald (DE), University of Virginia Health System (US), Leiden University Medical Center (NL), Novo Nordisk Foundation (DK), UCLA Medical Center (US), VA Boston Healthcare System (US), Erasmus MC (NL), Jackson Memorial Hospital (US), University of Mississippi Medical Center (US), University of Bristol (GB), Universität Greifswald (DE), University of Illinois Chicago (US), Hunter Medical Research Institute (AU), National Human Genome Research Institute (US), Alzheimer Scotland (GB), Kuopio University Hospital (FI), University of Texas Health Science Center at Dallas (US), Cancer Research And Biostatistics (US), Houston Health and Human Services Department (US), Brown Foundation (US), National Institute on Aging (US), Circadian (United States) (US), GGZ inGeest (NL), Atlanta VA Health Care System (US), Institute for Social Research (NO), Harbor–UCLA Medical Center (US), University College London (GB), Wake Forest University (US), University of Virginia (US), University of Tartu (EE), Case Western Reserve University (US), University of Regensburg (DE), University of Newcastle Australia (AU), Vanderbilt University Medical Center (US), The University of Texas Health Science Center at Houston (US), University of Colorado Denver (US), University of Edinburgh (GB)
National Institute for Health and Care Research, British Heart Foundation, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Novo Nordisk, Novo Nordisk Fonden, National Institutes of Health, Medical Research Council, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, Center for Information Technology
Openalex Percentile: Top 10%
Sleep and related disorders
2.12
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.