Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants
Collectively, the 17 (9 with short and 8 with long sleep) loci provided evidence into the biomolecular mechanisms underlying sleep-associated lipid changes, including potential involvement of the vitamin D receptor pathway. Collectively, these findings may contribute developing novel interventions for treating dyslipidemia in people with sleep disturbances.
Authors
- Natasha L. Pacheco (ORCID: https://orcid.org/0000-0002-9617-8887)
- Peter W.F. Wilson (ORCID: https://orcid.org/0000-0002-5653-7056)
- Traci M. Bartz (ORCID: https://orcid.org/0000-0003-3403-8763)
- Lisa de las Fuentes (ORCID: https://orcid.org/0000-0002-4689-325X)
- Clint L. Miller (ORCID: https://orcid.org/0000-0003-4276-3607)
- Todd L. Edwards (ORCID: https://orcid.org/0000-0003-4318-6119)
- John L. Morrison (ORCID: https://orcid.org/0000-0003-1478-9965)
- Patricia A. Peyser (ORCID: https://orcid.org/0000-0002-9717-8459)
- Takahisa Kawaguchi (ORCID: https://orcid.org/0000-0001-7781-7404)
- Zekai Chen (ORCID: https://orcid.org/0000-0003-2536-4532)
- Mart Kals (ORCID: https://orcid.org/0000-0003-2090-8780)
- Thomas C Russ
- Cashell E. Jaquish (ORCID: https://orcid.org/0000-0003-3319-3729)
- Xiaofeng Zhu (ORCID: https://orcid.org/0000-0003-0037-411X)
- Themistocles L. Assimes (ORCID: https://orcid.org/0000-0003-2349-0009)
- Annemarie I. Luik (ORCID: https://orcid.org/0000-0001-7517-197X)
- Ilja M. Nolte (ORCID: https://orcid.org/0000-0001-5047-4077)
- Songmi Lee (ORCID: https://orcid.org/0000-0001-6003-2336)
- Jill M. Norris (ORCID: https://orcid.org/0000-0001-8674-2598)
- Han Chen (ORCID: https://orcid.org/0000-0002-9510-4923)
- J. Michael Gaziano (ORCID: https://orcid.org/0000-0002-5384-9767)
- Renata L. Riha (ORCID: https://orcid.org/0000-0001-8983-9985)
- Yasuharu Tabara (ORCID: https://orcid.org/0000-0003-4505-7951)
- Hannah G. Polikowsky (ORCID: https://orcid.org/0000-0001-7226-9752)
- Christophe Lefèvre (ORCID: https://orcid.org/0000-0002-2876-0648)
- Botong Shen
- Raymond Noordam (ORCID: https://orcid.org/0000-0001-7801-809X)
- Pramod Anugu (ORCID: https://orcid.org/0000-0001-8157-8477)
- Zhijie Huang (ORCID: https://orcid.org/0000-0002-7312-4982)
- Qin Hui
- Patricia B. Munroe (ORCID: https://orcid.org/0000-0002-4176-2947)
- Changwei Li (ORCID: https://orcid.org/0000-0002-9203-304X)
- Ileana De Anda‐Duran (ORCID: https://orcid.org/0000-0003-3629-9465)
- Rui Xia (ORCID: https://orcid.org/0000-0003-2409-1181)
- Lauren E. Petty (ORCID: https://orcid.org/0000-0003-1619-6303)
- Susan P. Fisher‐Hoch (ORCID: https://orcid.org/0000-0002-7894-5114)
- D. C. Rao (ORCID: https://orcid.org/0009-0006-8538-2141)
- Jennifer Elizabeth Below (ORCID: https://orcid.org/0000-0002-1346-1872)
- Amy R. Bentley (ORCID: https://orcid.org/0000-0002-0827-9101)
- Sarah E. Harris (ORCID: https://orcid.org/0000-0002-4807-2578)
- Gregorio V. Linchangco (ORCID: https://orcid.org/0009-0001-2578-9947)
- Tamar Sofer (ORCID: https://orcid.org/0000-0001-8520-8860)
- James B. Meigs (ORCID: https://orcid.org/0000-0002-2439-2657)
- Mary F. Feitosa (ORCID: https://orcid.org/0000-0002-0933-2410)
- M. Arfan Ikram (ORCID: https://orcid.org/0000-0003-0372-8585)
- Dina Vojinović (ORCID: https://orcid.org/0000-0001-5744-0232)
- Alisa K. Manning (ORCID: https://orcid.org/0000-0003-0247-902X)
- Tariq Faquih (ORCID: https://orcid.org/0000-0001-8026-2251)
- Hans Jörgen Grabe (ORCID: https://orcid.org/0000-0003-3684-4208)
- Ayush Giri (ORCID: https://orcid.org/0000-0002-7786-4670)
- Edward Ruiz-Narváez (ORCID: https://orcid.org/0000-0002-0339-5824)
- Yan V. Sun (ORCID: https://orcid.org/0000-0002-2838-1824)
- Matthias Nauck (ORCID: https://orcid.org/0000-0002-6678-7964)
- Massimo Mangino (ORCID: https://orcid.org/0000-0002-2167-7470)
- Kristin L. Young (ORCID: https://orcid.org/0000-0003-0070-6145)
- Susan Redline
- Kenneth E. Westerman (ORCID: https://orcid.org/0000-0001-7619-1868)
- Laura M. Raffield (ORCID: https://orcid.org/0000-0002-7892-193X)
- Maris Teder‐Laving (ORCID: https://orcid.org/0000-0002-5872-1850)
- Tanika N. Kelly (ORCID: https://orcid.org/0000-0002-7348-4451)
- Kelly Cho (ORCID: https://orcid.org/0000-0003-1727-7076)
- Peter J. van der Most (ORCID: https://orcid.org/0000-0001-8450-3518)
- Lydia Bazzano (ORCID: https://orcid.org/0000-0002-8958-1352)
- Carrie A Karvonen-Gutierrez (ORCID: https://orcid.org/0000-0002-1950-5397)
- Joseph B. McCormick (ORCID: https://orcid.org/0000-0002-5844-8102)
- Laura D. Baker (ORCID: https://orcid.org/0000-0002-6217-7384)
- Yuri Milaneschi (ORCID: https://orcid.org/0000-0002-3697-6617)
- Christie Mitchell Ballantyne (ORCID: https://orcid.org/0000-0002-6432-1730)
- Pavithra Nagarajan (ORCID: https://orcid.org/0000-0002-0036-9970)
- John Attia (ORCID: https://orcid.org/0000-0001-9800-1308)
- James E. Hixson (ORCID: https://orcid.org/0000-0002-0849-9315)
- Quan Sun (ORCID: https://orcid.org/0000-0001-8324-2803)
- Paul S. de Vries (ORCID: https://orcid.org/0000-0003-0964-0111)
- Debbie A. Lawlor (ORCID: https://orcid.org/0000-0002-6793-2262)
- Brenda W.J.H. Penninx (ORCID: https://orcid.org/0000-0001-7779-9672)
- Tuomas O. Kilpeläinen (ORCID: https://orcid.org/0000-0002-8349-3028)
- Jennifer A. Smith (ORCID: https://orcid.org/0000-0002-3575-5468)
- Md Abu Yusuf Ansari (ORCID: https://orcid.org/0000-0001-9076-9320)
- Michelle M. Hood (ORCID: https://orcid.org/0000-0002-1049-8426)
- Kari E. North (ORCID: https://orcid.org/0000-0002-8903-0366)
- Mohsen Ghanbari (ORCID: https://orcid.org/0000-0002-9476-7143)
- Wenyi Wang (ORCID: https://orcid.org/0000-0002-3432-1713)
- Sami Heikkinen (ORCID: https://orcid.org/0000-0002-6083-2402)
- Stephen S. Rich (ORCID: https://orcid.org/0000-0003-3872-7793)
- Sioḃán D. Harlow (ORCID: https://orcid.org/0000-0002-9899-356X)
- Simon R. Cox (ORCID: https://orcid.org/0000-0003-4036-3642)
- Michael R. Brown (ORCID: https://orcid.org/0000-0002-5235-9037)
- Stefan Weiß (ORCID: https://orcid.org/0000-0002-3553-4315)
- Michael Y. Tsai (ORCID: https://orcid.org/0000-0001-7553-3408)
- Latchezar Dimitrov (ORCID: https://orcid.org/0000-0003-4417-3790)
- Serena C. Houghton (ORCID: https://orcid.org/0000-0001-8833-9065)
- Henry J. Lin (ORCID: https://orcid.org/0000-0001-6771-0486)
- Wei Zhao (ORCID: https://orcid.org/0000-0001-7388-0692)
- Cristina Menni (ORCID: https://orcid.org/0000-0001-9790-0571)
- Rima Destya Triatin (ORCID: https://orcid.org/0000-0001-9992-6345)
- Ko Willems van Dijk (ORCID: https://orcid.org/0000-0002-2172-7394)
- Varun Rao (ORCID: https://orcid.org/0000-0003-1535-5907)
- Aroon D. Hingorani (ORCID: https://orcid.org/0000-0001-8365-0081)
- Ching‐Ti Liu (ORCID: https://orcid.org/0000-0002-0703-0742)
- Yuk‐Lam Ho (ORCID: https://orcid.org/0000-0003-3305-3830)
- Hung‐Hsin Chen (ORCID: https://orcid.org/0000-0002-1921-2797)
- Sina A. Gharib (ORCID: https://orcid.org/0000-0002-2480-4367)
- Karen Schwander (ORCID: https://orcid.org/0000-0002-0193-4134)
- C. Charles Gu (ORCID: https://orcid.org/0000-0002-8527-8145)
- Lynne E. Wagenknecht (ORCID: https://orcid.org/0000-0002-9980-0889)
- Wei Chen (ORCID: https://orcid.org/0000-0003-1566-7943)
- Qian Yang (ORCID: https://orcid.org/0000-0003-2304-9408)
- Xiuqing Guo
- Mariaelisa Graff
- Fumihiko Matsuda
- Jie Yao (ORCID: https://orcid.org/0000-0001-5812-6624)
- Myriam Fornage
- Eric Boerwinkle
- Xu Hanfei
- Ruiyuan Zhang (ORCID: https://orcid.org/0000-0002-4639-3300)
- Kent D. Taylor
- Jingxian Tang
- Nora Franceschini
- Wanying Zhu (ORCID: https://orcid.org/0000-0002-2673-3048)
- Hugues Aschard
- Ervin R. Fox
- Heming Wang (ORCID: https://orcid.org/0000-0003-4426-6540)
- Henry Völzke
- Alan B Zonderman
- Yujie Wang (ORCID: https://orcid.org/0009-0000-9102-5497)
- Harold Snieder
- Alanna C. Morrison
- Michael A. Province
- Timo A Lakka
- Bruce M. Psaty
- Colleen M. Sitlani
- Reedik Mägi
- Anh Do
- Rainer Rauramaa
- Tim D. Spector
- Pirjo Komulainen
- Brain Cade
- Jintao Ma
- Aldi T. Kraja
- Yii-Der Ida Chen
- Michelle Evans
- Jiang He
- Jeffrey R. O’Connel
- W. James Gauderman
- Thomas Winkler (ORCID: https://orcid.org/0000-0002-3097-0230)
Institutions
- Broad Institute (US)
- Boston University (US)
- University of North Carolina at Chapel Hill (US)
- Tulane University (US)
- University of Southern California (US)
- Tufts University (US)
- University of Maryland, Baltimore (US)
- Brigham and Women's Hospital (US)
- National Institutes of Health (US)
- University of Minnesota (US)
- Beth Israel Deaconess Medical Center (US)
- NHS Lothian (GB)
- University Medical Center Groningen (NL)
- Emory University (US)
- Colorado School of Public Health (US)
- Institut Pasteur (FR)
- Queen Mary University of London (GB)
- University of Groningen (NL)
- University of Eastern Finland (FI)
- Baylor College of Medicine (US)
- King's College London (GB)
- University of Washington (US)
- Washington University in St. Louis (US)
- Université Paris Cité (FR)
- VA Palo Alto Health Care System (US)
- Kyoto University (JP)
- University of Michigan (US)
- Universitätsmedizin Greifswald (DE)
- University of Virginia Health System (US)
- Leiden University Medical Center (NL)
- Novo Nordisk Foundation (DK)
- UCLA Medical Center (US)
- VA Boston Healthcare System (US)
- Erasmus MC (NL)
- Jackson Memorial Hospital (US)
- University of Mississippi Medical Center (US)
- University of Bristol (GB)
- Universität Greifswald (DE)
- University of Illinois Chicago (US)
- Hunter Medical Research Institute (AU)
- National Human Genome Research Institute (US)
- Alzheimer Scotland (GB)
- Kuopio University Hospital (FI)
- University of Texas Health Science Center at Dallas (US)
- Cancer Research And Biostatistics (US)
- Houston Health and Human Services Department (US)
- Brown Foundation (US)
- National Institute on Aging (US)
- Circadian (United States) (US)
- GGZ inGeest (NL)
- Atlanta VA Health Care System (US)
- Institute for Social Research (NO)
- Harbor–UCLA Medical Center (US)
- University College London (GB)
- Wake Forest University (US)
- University of Virginia (US)
- University of Tartu (EE)
- Case Western Reserve University (US)
- University of Regensburg (DE)
- University of Newcastle Australia (AU)
- Vanderbilt University Medical Center (US)
- The University of Texas Health Science Center at Houston (US)
- University of Colorado Denver (US)
- University of Edinburgh (GB)
Publication Details
- Journal
- Atherosclerosis
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1016/j.atherosclerosis.2025.120603
- Citations
- 1
- Primary Topic
- Sleep and related disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.12
Funders
- National Institute for Health and Care Research
- British Heart Foundation
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Novo Nordisk
- Novo Nordisk Fonden
- National Institutes of Health
- Medical Research Council
- National Heart, Lung, and Blood Institute
- National Institute of Diabetes and Digestive and Kidney Diseases
- Center for Information Technology