A non-affinity-dependent high-resolution mass spectrometry method for detecting and typing monoclonal free light immunoglobulin chains
The HRMS method presented can detect, isotype, and semi-quantify monoclonal monomeric and dimeric light chains in serum, as well as demonstrate post-translational modifications. It is a selective, non-affinity-dependent method with a simple workflow that has the potential to become a valuable tool in the management of B-cell diseases.
Authors
- Magnus Förnvik Jonsson (ORCID: https://orcid.org/0000-0002-9227-744X)
- Per Bengtson (ORCID: https://orcid.org/0000-0002-6762-3443)
Institutions
- Lund University (SE)
- Skåne University Hospital (SE)
- Hallands sjukhus Halmstad (SE)
Publication Details
- Journal
- Journal of Mass Spectrometry and Advances in the Clinical Lab
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1016/j.jmsacl.2025.11.004
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00