Therapy related myelodysplastic syndrome: a hematologic sequela of low dose methotrexate in rheumatoid arthritis
This case highlights the potential for low-dose MTX to cause t-MDS, which may be reversible if detected early. As serum MTX levels do not correlate with toxicity, regular blood count monitoring is essential. Prompt drug withdrawal and supportive therapy can lead to full recovery and prevent permanent marrow damage.
Authors
- D Venugopala
- Alam Nawaz (ORCID: https://orcid.org/0000-0002-5253-0025)
- A Gupta (ORCID: https://orcid.org/0009-0002-0804-0974)
- V Hari (ORCID: https://orcid.org/0009-0004-3821-8117)
Institutions
- Manipal Academy of Higher Education (IN)
Publication Details
- Journal
- Oxford Medical Case Reports
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1093/omcr/omaf253
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00