Myrrhain A: Structural Reassignment Highlights the Relevance of Plasticizer Contamination in Chemical and Bioactivity Studies
The proposed structure for myrrhain A, containing an unlikely 1,2-di-<i>t</i>-butylbenzofuran substitution pattern, was reassigned as a known plasticizer by direct spectroscopic comparison and Computer Assisted Structure Elucidation (CASE). Concerningly, plasticizers and their precursors, degradation and/or oxidation products, arising from environmental or laboratory contamination, continue to be misconstrued as natural products.
Authors
- Andrei G. Kutateladze (ORCID: https://orcid.org/0000-0003-3066-517X)
- Giovanni Appendino (ORCID: https://orcid.org/0000-0002-4170-9919)
- Mikhail Elyashberg (ORCID: https://orcid.org/0000-0001-9736-2427)
- Craig M. Williams (ORCID: https://orcid.org/0000-0002-3834-7398)
- Roderick W. Bates (ORCID: https://orcid.org/0000-0002-8115-4970)
- Sopan Pralhad Khandare
Institutions
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- University of Denver (US)
- Queensland University of Technology (AU)
- The University of Queensland (AU)
- Nanyang Technological University (SG)
- BioScience Laboratories (United States) (US)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1021/acs.orglett.5c04575
- Citations
- 2
- Primary Topic
- Pharmacological Effects of Medicinal Plants
- Type
- article
- Field-Weighted Citation Impact
- 2.79