Extracellular vesicles from Yiguanjian-primed bone-marrow mesenchymal stem cells ameliorate chronic liver fibrosis via miR-7045-5p
YGJ increases miR-7045-5p abundance in BMSC-EVs. YGJ-EVs alleviate liver fibrosis by delivering the anti-fibrotic miRNA miR-7045-5p, which inhibits the Akt/AMPK/TFEB pathway, thereby promoting lysosomal biogenesis and mitophagy in HSCs.
Authors
- Chongyang Ma (ORCID: https://orcid.org/0000-0003-1481-8017)
- Zuoqing Tang
- Hongjie You
- Zhejun Liu
- Yun Ma
- Wenlan Liu (ORCID: https://orcid.org/0000-0003-2400-2791)
- Xiaodan Jiang
- Niancong Che
Institutions
- Nanjing University of Chinese Medicine (CN)
- Capital Medical University (CN)
- Suzhou Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s13287-025-04780-x
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81