High-Dose vs Standard-Dose Influenza Vaccine in Chronic Kidney Disease
In this prespecified analysis of DANFLU-2, including the largest CKD population ever in an individually randomized vaccine trial, we observed a benefit of HD-IIV vs SD-IIV against hospitalization for influenza or pneumonia, as well as hospitalization for influenza, with suggestion of a greater relative benefit among those with CKD. Furthermore, the beneficial effect of HD-IIV vs SD-IIV on multiple cardiorespiratory outcomes was consistent across participants irrespective of CKD status.
Authors
- Nino Emanuel Landler (ORCID: https://orcid.org/0000-0001-5255-787X)
- Katja Vu Bartholdy
- Brian Lee Claggett (ORCID: https://orcid.org/0000-0002-4215-9218)
- Lothar Wiese (ORCID: https://orcid.org/0000-0003-2719-1743)
- Caroline Espersen (ORCID: https://orcid.org/0000-0003-2879-8862)
- Morten Sengeløv (ORCID: https://orcid.org/0000-0002-2139-8068)
- Matthew M. Loiacono (ORCID: https://orcid.org/0000-0001-8100-465X)
- Lise Witten Davodian
- Camilla Ikast Ottosen (ORCID: https://orcid.org/0000-0002-8446-6216)
- Kristoffer Grundtvig Skaarup (ORCID: https://orcid.org/0000-0002-2690-7511)
- Adam Cadovius Femerling Langhoff (ORCID: https://orcid.org/0000-0002-6073-2938)
- Lars Køber (ORCID: https://orcid.org/0000-0002-6635-1466)
- Mats Christian Højbjerg Lassen (ORCID: https://orcid.org/0000-0002-2255-582X)
- Gunnar Gislason (ORCID: https://orcid.org/0000-0002-0548-402X)
- Jens‐Ulrik Stæhr Jensen (ORCID: https://orcid.org/0000-0003-4036-0521)
- Marine Dufournet (ORCID: https://orcid.org/0009-0009-8389-4479)
- Filip Soeskov Davidovski (ORCID: https://orcid.org/0000-0002-6642-416X)
- Lisa Steen Duus (ORCID: https://orcid.org/0000-0003-4110-3199)
- Carsten Schade Larsen (ORCID: https://orcid.org/0000-0002-3963-3804)
- Anne Bjerg Nielsen (ORCID: https://orcid.org/0000-0002-0624-5936)
- Daniel Modin (ORCID: https://orcid.org/0000-0002-7566-0519)
- Maria Dons (ORCID: https://orcid.org/0000-0003-3506-6862)
- Cyril Jean‐Marie Martel (ORCID: https://orcid.org/0009-0004-3371-6870)
- Rebecca C. Harris (ORCID: https://orcid.org/0000-0002-2636-1520)
- Michael Dalager‐Pedersen (ORCID: https://orcid.org/0000-0002-3220-2526)
- Martin Landray (ORCID: https://orcid.org/0000-0001-6646-827X)
- Niklas Dyrby Johansen (ORCID: https://orcid.org/0000-0001-6959-3236)
- Tor Biering‐Sørensen (ORCID: https://orcid.org/0000-0003-4209-2778)
- Pradeesh Sivapalan (ORCID: https://orcid.org/0000-0002-8620-3655)
- Katrine Feldballe Bernholm (ORCID: https://orcid.org/0000-0001-5324-9430)
- Julie Borchsenius
- Frederik Holme Fussing (ORCID: https://orcid.org/0009-0001-8710-6945)
- Anne Jensen (ORCID: https://orcid.org/0000-0001-8311-8693)
- Lykke Larsen (ORCID: https://orcid.org/0000-0002-4113-4182)
- Scott D Solomon
Institutions
- Statens Serum Institut (DK)
- University of Copenhagen (DK)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Aalborg University Hospital (DK)
- Odense University Hospital (DK)
- Aarhus University Hospital (DK)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Sanofi (France) (FR)
- University of Oxford (GB)
- Zealand University Hospital (DK)
- Heart Foundation (US)
- University of Delaware (US)
Publication Details
- Journal
- Journal of the American College of Cardiology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1016/j.jacc.2025.10.005
- Citations
- 1
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35