Acute appendicitis in children with malignancy

Both surgical treatment and conservative management with broad-spectrum antibiotics are safe options for acute appendicitis in children with malignant tumors. However, due to significant selection bias in treatment allocation, our findings should be interpreted as descriptive rather than comparative. The observed shorter hospital stay in the laparoscopic appendectomy subgroup requires validation in prospective studies with appropriate adjustment for confounding factors. Treatment decisions should be individualized based on clinical presentation, neutropenia status, and multidisciplinary team assessment.