Donor-dependent heterogeneity in therapeutic effects of adipose tissue extracellular vesicles
Our findings indicate that further research is needed to identify critical donor characteristics that predict therapeutic ability of individual or pooled adipose tissue-derived EVs to reduce inflammation and fibrosis.
Authors
- Dalila Iannotta (ORCID: https://orcid.org/0000-0002-9189-4382)
- Danielle J. Beetler (ORCID: https://orcid.org/0000-0003-1767-5701)
- Katelyn A. Bruno (ORCID: https://orcid.org/0000-0001-8980-6059)
- Matthew E. Auda (ORCID: https://orcid.org/0000-0002-3679-5365)
- Emily R. Whelan (ORCID: https://orcid.org/0000-0002-0410-0549)
- Anthony Pham (ORCID: https://orcid.org/0000-0002-5496-0301)
- Axel Puls (ORCID: https://orcid.org/0009-0004-9802-1455)
- Houssam Farres (ORCID: https://orcid.org/0000-0002-5740-1601)
- David J. Gorelov
- Logan P. Macomb (ORCID: https://orcid.org/0000-0002-0022-8510)
- Kevin C. Keegan (ORCID: https://orcid.org/0000-0003-2911-4725)
- Leslie T. Cooper (ORCID: https://orcid.org/0000-0003-1002-3313)
- Presley Giresi (ORCID: https://orcid.org/0000-0002-0095-6198)
- Varsini Balamurugan
- Shane A. Shapiro (ORCID: https://orcid.org/0000-0001-5753-0625)
- Brandy Edenfield (ORCID: https://orcid.org/0009-0005-5571-9500)
- Sierra A. Walker (ORCID: https://orcid.org/0000-0002-9201-0833)
- Angita Jain (ORCID: https://orcid.org/0000-0003-1391-8139)
- Joy Wolfram (ORCID: https://orcid.org/0000-0003-0579-9897)
- Sami Khatib (ORCID: https://orcid.org/0000-0002-4458-471X)
- DeLisa Fairweather (ORCID: https://orcid.org/0000-0003-3093-1810)
- Damian Nicolas Di Florio (ORCID: https://orcid.org/0000-0003-1619-5394)
- Jessica J. Fliess (ORCID: https://orcid.org/0009-0004-7689-3172)
- Vivian Xu (ORCID: https://orcid.org/0000-0002-6649-9081)
- Molly M. Watkins (ORCID: https://orcid.org/0000-0001-9657-3142)
- Elizabeth J McCabe (ORCID: https://orcid.org/0000-0001-6711-4051)
- Gabriel J. Weigel (ORCID: https://orcid.org/0009-0009-7410-923X)
Institutions
- Mayo Clinic (US)
- The University of Queensland (AU)
- Jacksonville College (US)
- WinnMed (US)
- University of Florida (US)
- Jacksonville University (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s12964-025-02563-8
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00