Combining Pirfenidone With Mycophenolate Mofetil for Systemic Sclerosis–Related Interstitial Lung Disease (Scleroderma Lung Study <scp>III</scp> ): An Investigator‐Initiated, Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Phase 2 Trial
In this underpowered study, there was no statistically significant treatment difference in overall change in FVC-% between groups. MMF+PFD was not as well tolerated as MMF+PLA.
Authors
- Michael D. Roth (ORCID: https://orcid.org/0000-0003-2194-6578)
- Marcin A. Trojanowski (ORCID: https://orcid.org/0000-0003-2583-1591)
- Gary Matthew Hunninghake (ORCID: https://orcid.org/0000-0001-9782-2841)
- Mary Beth Scholand (ORCID: https://orcid.org/0000-0001-6513-8893)
- Ganesh Raghu (ORCID: https://orcid.org/0000-0001-7506-6643)
- Maureen D. Mayes (ORCID: https://orcid.org/0000-0001-5070-2535)
- Richard McLain
- R. Boente (ORCID: https://orcid.org/0000-0003-3750-1311)
- Jane E. Dematte (ORCID: https://orcid.org/0000-0003-4907-9525)
- Eric C. Kleerup
- Iván O. Rosas (ORCID: https://orcid.org/0000-0003-4622-618X)
- Aryeh Fischer (ORCID: https://orcid.org/0000-0003-2024-6780)
- Cathie Spino (ORCID: https://orcid.org/0000-0002-6157-6738)
- Jonathan Goldin (ORCID: https://orcid.org/0000-0003-3007-9947)
- Elana J. Bernstein (ORCID: https://orcid.org/0000-0001-5560-6390)
- Virginia Steen (ORCID: https://orcid.org/0000-0002-6333-0133)
- Airi Harui
- Vivien Hsu (ORCID: https://orcid.org/0000-0002-9588-347X)
- Donald P. Tashkin (ORCID: https://orcid.org/0000-0002-5607-4872)
- Vivek Nagaraja (ORCID: https://orcid.org/0000-0002-4930-3200)
- Grace Hyun J. Kim (ORCID: https://orcid.org/0000-0003-1225-3489)
- Paul F. Dellaripa (ORCID: https://orcid.org/0000-0003-0237-739X)
- Dinesh Khanna (ORCID: https://orcid.org/0000-0003-1412-4453)
- Robyn T. Domsic (ORCID: https://orcid.org/0000-0002-2765-0922)
- Jessica Gordon (ORCID: https://orcid.org/0000-0001-8068-0592)
- Richard M. Silver (ORCID: https://orcid.org/0000-0002-2038-3278)
- Robert W. Simms (ORCID: https://orcid.org/0000-0002-0101-1807)
- Grace Ibrahim
- Joyce Lee (ORCID: https://orcid.org/0000-0002-5758-8365)
- Suiyuan Huang
- Yi‐Hsuan Tu
- S. Samuel Weigt
Institutions
- Rutgers, The State University of New Jersey (US)
- Boston University (US)
- Northwestern University (US)
- Hospital for Special Surgery (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Medical University of South Carolina (US)
- University of California, Los Angeles (US)
- Eli Lilly (United States) (US)
- University of Pittsburgh (US)
- Georgetown University (US)
- University of Washington (US)
- University of Utah (US)
- University of Michigan (US)
- Columbia University Irving Medical Center (US)
- Georgetown University Medical Center (US)
- Johnson University (US)
- Mayo Clinic in Arizona (US)
- The University of Texas Health Science Center (US)
- Indiana University School of Medicine
- University of Colorado Anschutz Medical Campus (US)
- Indiana University – Purdue University Indianapolis (US)
- Seattle University (US)
Publication Details
- Journal
- ACR Open Rheumatology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1002/acr2.70126
- Citations
- 1
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Massachusetts General Hospital
- Genentech