FN-1501 Synergistically Enhances Almonertinib Efficacy in EGFR-TKI-ResistantLung Adenocarcinoma through Ferroptosis Induction
FN-1501 exhibits significant antitumor activity and, when combined with Alm, effectively reverses EGFR-TKI resistance by inducing ferroptosis, highlighting its potential for clinical application.
Authors
- Bowen Hu (ORCID: https://orcid.org/0000-0001-9815-8938)
- Dan Zou
- Yuxin Du (ORCID: https://orcid.org/0000-0001-7429-3238)
- Shiying Zhu (ORCID: https://orcid.org/0009-0006-0335-9328)
- Sitong Feng (ORCID: https://orcid.org/0000-0003-2320-1537)
- Shaodi Wen (ORCID: https://orcid.org/0000-0001-7951-0123)
- Bo Shen (ORCID: https://orcid.org/0000-0002-7229-4840)
- Peng Chen (ORCID: https://orcid.org/0000-0001-8462-2875)
Institutions
- Huaian First People’s Hospital (CN)
- Wuxi Fourth People's Hospital (CN)
- Jiangsu Cancer Hospital (CN)
- Xuzhou Central Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Anti-Cancer Agents in Medicinal Chemistry
- Published
- 2025-11-25
- DOI
- https://doi.org/10.2174/0118715206437150251113065146
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00