Safety and Immunogenicity of a Severe Acute Respiratory Syndrome Coronavirus 2 Spike Subunit Vaccine Stabilized in the Prefusion Conformation by a Second-Generation Molecular Clamp and Evaluated in Adults Aged 18–55 Years: A Randomized, Double-Blind,
UQSC2 was as well tolerated as the authorized comparator vaccine and produced an equally robust boost in neutralizing immune response. These findings support the effectiveness of the MC2 platform in producing vaccines against newly emerging variants of SARS-CoV-2 and other respiratory viruses, as well as the platform's potential use in emergency response to novel viruses.
Authors
- Karen Hughes (ORCID: https://orcid.org/0000-0001-8097-3395)
- Justin B. Goh (ORCID: https://orcid.org/0000-0002-4982-193X)
- Marianne Gillard (ORCID: https://orcid.org/0000-0002-2233-9975)
- Jillian Bennet (ORCID: https://orcid.org/0000-0002-1983-8642)
- Julia Lackenby (ORCID: https://orcid.org/0000-0003-0933-3998)
- Alberto A. Amarilla (ORCID: https://orcid.org/0000-0002-6640-3377)
- Daniel Watterson (ORCID: https://orcid.org/0000-0001-5957-2853)
- Trent P. Munro (ORCID: https://orcid.org/0000-0003-1987-2020)
- Keith J. Chappell (ORCID: https://orcid.org/0000-0001-8636-5067)
- Kym Hoger
- Vivian Kienzle (ORCID: https://orcid.org/0000-0001-7234-5794)
- Nicolas Tardiota (ORCID: https://orcid.org/0000-0002-4594-473X)
- Martina L. Jones (ORCID: https://orcid.org/0000-0002-5154-6017)
- Benjamin Liang (ORCID: https://orcid.org/0000-0003-3304-4715)
- Charani Ranasinghe (ORCID: https://orcid.org/0000-0002-6185-6940)
- Jake S. O’Donnell (ORCID: https://orcid.org/0000-0003-2960-7992)
- Zheyi Li (ORCID: https://orcid.org/0009-0008-5491-957X)
- Benjamin Hughes (ORCID: https://orcid.org/0009-0000-3289-2195)
- Rhiannon L. Dalrymple (ORCID: https://orcid.org/0000-0002-2660-1424)
- Patrick C. Reading (ORCID: https://orcid.org/0000-0002-8860-5308)
- Noushin Jaberolansar (ORCID: https://orcid.org/0000-0003-4700-0158)
- Christina L Henderson (ORCID: https://orcid.org/0000-0002-3374-6007)
- Paul R. Young (ORCID: https://orcid.org/0000-0002-2040-5190)
- Kanta Subbarao (ORCID: https://orcid.org/0000-0003-1713-3056)
- James Barnes (ORCID: https://orcid.org/0000-0001-9715-3668)
- Francesca L. Mordant (ORCID: https://orcid.org/0000-0002-3754-2642)
- Naphak Modhiran (ORCID: https://orcid.org/0000-0003-3205-4970)
- Varsha Kommajosyula
Institutions
- Australian National University (AU)
- The University of Queensland (AU)
- Peter Doherty Institute (AU)
- Oldham Council (GB)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1093/infdis/jiaf568
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00